View : 35 Download: 1

Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy

Title
Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy
Authors
Yee, JeongKim, WoorimChang, Byung ChulChung, Jee EunLee, Kyung EunGwak, Hye Sun
Ewha Authors
곽혜선
SCOPUS Author ID
곽혜선scopus
Issue Date
2019
Journal Title
DRUG DESIGN DEVELOPMENT AND THERAPY
ISSN
1177-8881JCR Link
Citation
DRUG DESIGN DEVELOPMENT AND THERAPY vol. 13, pp. 1717 - 1727
Keywords
GATA4GATA6warfarinbleedingpolymorphism
Publisher
DOVE MEDICAL PRESS LTD
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Purpose: GATA4 and GATA6 are known to have potential roles in vascular regulation by affecting vascular smooth muscle cell differentiation and atrial natriuretic peptide levels. The aim of this retrospective study was to investigate the associations between GATA4 and GATA6 polymorphisms and bleeding complication risk at a therapeutic international normalized ratio (INR) in patients with mechanical heart valves. Patients and methods: Study patients were included from the Ewha-Severance Treatment (EAST) Group of Warfarin. It consisted of 229 patients who received warfarin therapy after undergoing mechanical heart valve replacement and maintained a stable INR (INR of 2.0-3.0 for at least three consecutive times). Twenty single-nucleotide polymorphisms including VKORC1, CYP2C9, GATA4, and GATA6 were analyzed. Multivariate logistic regression analysis was employed to investigate the independent risk factors for bleeding complications. To evaluate the potential clinical value of genotyping for preventing bleeding complications in patients with high-risk genotype, the number needed to genotype (NNG) was also calculated. Results: One hundred forty-two patients were included in this study, 21 of whom had bleeding complications. After adjusting covariates, TT genotype carriers of rs13273672 in GATA4 and CC genotype carriers of rs10454095 in GATA6 showed 5.0- (95% CI, 1.6-15.7) and 3.1-fold (95% CI, 1.1-8.7) higher bleeding complications than carriers of C allele and T allele, respectively. NNG for preventing one patient from experiencing bleeding complications in patients with TT genotype of rs13273672 and CC genotype of rs10454095 was 22.2 and 17.5, respectively. Patients with both TT genotype in rs13273672 and CC genotype in rs10454095 showed 8.7-fold (95% CI, 1.7-46.1) higher bleeding complications than those with other genotypes. NNG in patients having both TT genotype in rs13273672 and CC genotype in rs10454095 was calculated to be 40.0. Conclusions: This study showed that GATA4 and GATA6 gene polymorphisms could affect bleeding complications during warfarin treatment in patients with mechanical heart valves.
DOI
10.2147/DDDT.S198018
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
Genetic variations in the transcription factors.pdf(1.73 MB) Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE