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A Review of the Microbial Production of Bioactive Natural Products and Biologics

Title
A Review of the Microbial Production of Bioactive Natural Products and Biologics
Authors
Pham, Janette, VYilma, Mariamawit A.Feliz, AdrianaMajid, Murtadha T.Maffetone, NicholasWalker, Jorge R.Kim, EunjiCho, Hyo JeReynolds, Jared M.Song, Myoung ChongPark, Sung RyeolYoon, Yeo Joon
Ewha Authors
윤여준송명종
SCOPUS Author ID
윤여준scopus; 송명종scopus
Issue Date
2019
Journal Title
FRONTIERS IN MICROBIOLOGY
ISSN
1664-302XJCR Link
Citation
FRONTIERS IN MICROBIOLOGY vol. 10
Keywords
natural productsbiologicsbiological activitymicrobial cell factoriesgenetic engineeringcombinatorial biosynthesisproduction improvement
Publisher
FRONTIERS MEDIA SA
Indexed
SCIE; SCOPUS WOS
Document Type
Review
Abstract
A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites, also known as natural products. Natural products have been a prolific source and an inspiration for numerous medical agents with widely divergent chemical structures and biological activities, including antimicrobial, immunosuppressive, anticancer, and anti-inflammatory activities, many of which have been developed as treatments and have potential therapeutic applications for human diseases. Aside from natural products, the recent development of recombinant DNA technology has sparked the development of a wide array of biopharmaceutical products, such as recombinant proteins, offering significant advances in treating a broad spectrum of medical illnesses and conditions. Herein, we will introduce the structures and diverse biological activities of natural products and recombinant proteins that have been exploited as valuable molecules in medicine, agriculture and insect control. In addition, we will explore past and ongoing efforts along with achievements in the development of robust and promising microorganisms as cell factories to produce biologically active molecules. Furthermore, we will review multi-disciplinary and comprehensive engineering approaches directed at improving yields of microbial production of natural products and proteins and generating novel molecules. Throughout this article, we will suggest ways in which microbial-derived biologically active molecular entities and their analogs could continue to inspire the development of new therapeutic agents in academia and industry.
DOI
10.3389/fmicb.2019.01404
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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