View : 542 Download: 0
Antibacterial activities of Cu-MOFs containing glutarates and bipyridyl ligands
- Title
- Antibacterial activities of Cu-MOFs containing glutarates and bipyridyl ligands
- Authors
- Jo, Jin Hyoung; Kim, Hyun-Chul; Huh, Seong; Kim, Youngmee; Lee, Do Nam
- Ewha Authors
- 김영미
- SCOPUS Author ID
- 김영미
- Issue Date
- 2019
- Journal Title
- DALTON TRANSACTIONS
- ISSN
- 1477-9226
1477-9234
- Citation
- DALTON TRANSACTIONS vol. 48, no. 23, pp. 8084 - 8093
- Publisher
- ROYAL SOC CHEMISTRY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Metal-organic frameworks (MOFs) can be utilized as antibacterial agents due to their effective antibacterial activities. Four three-dimensional (3D) Cu-MOFs formulated as [Cu-2(Glu)(2)(mu-L)]center dot x(H2O) (Glu is glutarate, and L is bpy = 4,4'-bipyridine (1), bpa = 1,2-bis(4-pyridyl) ethane (2), bpe = 1,2-bis(4-pyridyl) ethylene (3), and bpp = 1,2-bis(4-pyridyl) propane (4)) were synthesized by hydrothermal reactions or modified literature methods. Their solid-state structures were slightly modified to increase their hydrolytic stabilities in aqueous solution. Despite the seemingly sufficient void spaces in all the solvent-free MOFs, only the thermally activated form of MOF 2 displayed selective gas uptake ability for CO2 over N-2 and H-2. The antibacterial activities of the four Cu-MOFs, 1, 2, 3, and 4, were investigated by determining their minimal bactericidal concentration (MBC) values against five strains of bacteria, including E. coli, S. aureus, K. pneumonia, P. aeruginosa, and MRSA, which can be easily met in our daily surrounding environments. Although these Cu-MOFs were found to be structurally very stable in aqueous medium during antibacterial activity tests, they exhibited excellent antibacterial activities against all five kinds of bacteria, including Gram-positive bacteria (S. aureus and MRSA) and Gram-negative bacteria (E. coli, K. pneumonia, and P. aeruginosa), with very low MBCs. The robust 3D frameworks with surface active metal sites rather than the small amount of leached Cu-II ions may participate more strongly in inactivating various kinds of bacteria and reduce potential cytotoxicity mainly caused by leached metal ions.
- DOI
- 10.1039/c9dt00791a
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML