Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.date.accessioned | 2019-07-22T16:30:16Z | - |
dc.date.available | 2019-07-22T16:30:16Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1936-0851 | * |
dc.identifier.other | OAK-25034 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/250096 | - |
dc.description.abstract | A major challenge in cancer treatment is the development of effective tumor-specific therapeutic methods that have minimal side effects. Recently, a photodynamic therapy (PDT) technique using activatable photosensitizers (aPSs) has shown great potential for cancer-specific treatment. Here, we develop a sequential protein-responsive aPS (PcC4-MSN-O1) that is based on zinc(II) phthalocyanine derivative (PcC4)-entrapped mesoporous silica nanoparticles (MSNs) and a wrapping DNA (O1) as a biogate. Inside the nanostructure of PcC4-MSN-O1, PcC4 shows self-quenching photoactivity. However, when PcC4-MSN-O1 sequentially reacts with telomerase and albumin, its photoactivity is dramatically turned on. Therefore, PcC4-MSN-O1 displays selective phototoxicity against cancer cells (e.g., HeLa) over normal cells (e.g., HEK-293). Following systemic PcC4-MSN-O1 administration, there is an obvious accumulation in HeLa tumors of xenograft-bearing mice, and laser irradiation clearly induces the inhibition of tumor growth. Moreover, the time-modulated activation process in tumors and the relatively fast excretion of PcC4-MSN-O1 indicate its advantages in reducing potential side effects. © 2019 American Chemical Society. | * |
dc.language | English | * |
dc.publisher | American Chemical Society | * |
dc.subject | activatable | * |
dc.subject | Nanophotosensitizer | * |
dc.subject | photodynamic therapy | * |
dc.subject | phthalocyanine | * |
dc.subject | protein-responsive | * |
dc.title | Sequential Protein-Responsive Nanophotosensitizer Complex for Enhancing Tumor-Specific Therapy | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 6702 | * |
dc.relation.lastpage | 6710 | * |
dc.relation.journaltitle | ACS Nano | * |
dc.identifier.doi | 10.1021/acsnano.9b01100 | * |
dc.identifier.wosid | WOS:000473248300054 | * |
dc.identifier.scopusid | 2-s2.0-85067412997 | * |
dc.author.google | Li X. | * |
dc.author.google | Fan H. | * |
dc.author.google | Guo T. | * |
dc.author.google | Bai H. | * |
dc.author.google | Kwon N. | * |
dc.author.google | Kim K.H. | * |
dc.author.google | Yu S. | * |
dc.author.google | Cho Y. | * |
dc.author.google | Kim H. | * |
dc.author.google | Nam K.T. | * |
dc.author.google | Yoon J. | * |
dc.author.google | Zhang X.-B. | * |
dc.author.google | Tan W. | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.date.modifydate | 20240118162450 | * |