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약학대학
약학과
Journal papers
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Recent therapeutic trends and promising targets in triple negative breast cancer
Title
Recent therapeutic trends and promising targets in triple negative breast cancer
Authors
Hwang S.-Y.
;
Park S.
;
Kwon Y.
Ewha Authors
권영주
SCOPUS Author ID
권영주
Issue Date
2019
Journal Title
Pharmacology and Therapeutics
ISSN
0163-7258
Citation
Pharmacology and Therapeutics vol. 199, pp. 30 - 57
Keywords
Clinical trials
;
Experimental targets
;
Metastatic triple negative breast cancer (mTNBC)
;
Preclinical implication
;
Small molecules
;
Targeted therapy
Publisher
Elsevier Inc.
Indexed
SCIE; SCOPUS
Document Type
Review
Abstract
Breast cancer accounts for 25% of all types of cancer in women, and triple negative breast cancer (TNBC) comprises around 15~20% of breast cancers. Conventional chemotherapy and radiation are the primary systemic therapeutic strategies; no other FDA-approved targeted therapies are yet available as for TNBC. TNBC is generally characterized by a poor prognosis and high rates of proliferation and metastases. Due to these aggressive features and lack of targeted therapies, numerous attempts have been made to discover viable molecular targets for TNBC. Massive cohort studies, clinical trials, and in-depth analyses have revealed diverse molecular alterations in TNBC; however, controversy exists as to whether many of these changes are beneficial or detrimental in caner progression. Here we review the complicated tumorigenic processes and discuss critical findings and therapeutic trends in TNBC with a focus on promising therapeutic approaches, the clinical trials currently underway, and potent experimental compounds under preclinical and evaluation. © 2019 The Authors
DOI
10.1016/j.pharmthera.2019.02.006
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