Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 곽혜선 | * |
dc.date.accessioned | 2019-06-07T16:30:04Z | - |
dc.date.available | 2019-06-07T16:30:04Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 0009-9236 | * |
dc.identifier.issn | 1532-6535 | * |
dc.identifier.other | OAK-24870 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249959 | - |
dc.description.abstract | The cytochrome P450 (CYP)4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at the individual patients level to capture the possible effect of ethnicity, gene-gene interaction, or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta-analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients' data. The final collection consists of 15,754 patients split into a derivation and validation cohort. The CYP4F2*3 polymorphism was consistently associated with an increase in mean coumarin dose (+9% (95% confidence interval (CI) 7-10%), with a higher effect in women, in patients taking acenocoumarol, and in white patients. The inclusion of the CYP4F2*3 in dosing algorithms slightly improved the prediction of stable coumarin dose. New pharmacogenetic equations potentially useful for clinical practice were derived. | * |
dc.language | English | * |
dc.publisher | WILEY | * |
dc.title | Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 105 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1477 | * |
dc.relation.lastpage | 1491 | * |
dc.relation.journaltitle | CLINICAL PHARMACOLOGY & THERAPEUTICS | * |
dc.identifier.doi | 10.1002/cpt.1323 | * |
dc.identifier.wosid | WOS:000467751900030 | * |
dc.identifier.scopusid | 2-s2.0-85061927761 | * |
dc.author.google | Danese, Elisa | * |
dc.author.google | Raimondi, Sara | * |
dc.author.google | Montagnana, Martina | * |
dc.author.google | Tagetti, Angela | * |
dc.author.google | Langaee, Taimour | * |
dc.author.google | Borgiani, Paola | * |
dc.author.google | Ciccacci, Cinzia | * |
dc.author.google | Carcas, Antonio J. | * |
dc.author.google | Borobia, Alberto M. | * |
dc.author.google | Tong, Hoi Y. | * |
dc.author.google | Davila-Fajardo, Cristina | * |
dc.author.google | Botton, Mariana Rodrigues | * |
dc.author.google | Bourgeois, Stephane | * |
dc.author.google | Deloukas, Panos | * |
dc.author.google | Caldwell, Michael D. | * |
dc.author.google | Burmester, Jim K. | * |
dc.author.google | Berg, Richard L. | * |
dc.author.google | Cavallari, Larisa H. | * |
dc.author.google | Drozda, Katarzyna | * |
dc.author.google | Huang, Min | * |
dc.author.google | Zhao, Li-Zi | * |
dc.author.google | Cen, Han-Jing | * |
dc.author.google | Gonzalez-Conejero, Rocio | * |
dc.author.google | Roldan, Vanessa | * |
dc.author.google | Nakamura, Yusuke | * |
dc.author.google | Mushiroda, Taisei | * |
dc.author.google | Gong, Inna Y. | * |
dc.author.google | Kim, Richard B. | * |
dc.author.google | Hirai, Keita | * |
dc.author.google | Itoh, Kunihiko | * |
dc.author.google | Isaza, Carlos | * |
dc.author.google | Beltran, Leonardo | * |
dc.author.google | Jimenez-Varo, Enrique | * |
dc.author.google | Canadas-Garre, Marisa | * |
dc.author.google | Giontella, Alice | * |
dc.author.google | Kringen, Marianne K. | * |
dc.author.google | Haug, Kari Bente Foss | * |
dc.author.google | Gwak, Hye Sun | * |
dc.author.google | Lee, Kyung Eun | * |
dc.author.google | Minuz, Pietro | * |
dc.author.google | Lee, Ming Ta Michael | * |
dc.author.google | Lubitz, Steven A. | * |
dc.author.google | Scott, Stuart | * |
dc.author.google | Mazzaccara, Cristina | * |
dc.author.google | Sacchetti, Lucia | * |
dc.author.google | Genc, Ece | * |
dc.author.google | Ozer, Mahmut | * |
dc.author.google | Pathare, Anil | * |
dc.author.google | Krishnamoorthy, Rajagopal | * |
dc.author.google | Paldi, Andras | * |
dc.author.google | Siguret, Virginie | * |
dc.author.google | Loriot, Marie-Anne | * |
dc.author.google | Kutala, Vijay Kumar | * |
dc.author.google | Suarez-Kurtz, Guilherme | * |
dc.author.google | Perini, Jamila | * |
dc.author.google | Denny, Josh C. | * |
dc.author.google | Ramirez, Andrea H. | * |
dc.author.google | Mittal, Balraj | * |
dc.author.google | Rathore, Saurabh Singh | * |
dc.author.google | Sagreiya, Hersh | * |
dc.author.google | Altman, Russ | * |
dc.author.google | Shahin, Mohamed Hossam A. | * |
dc.author.google | Khalifa, Sherief, I | * |
dc.author.google | Limdi, Nita A. | * |
dc.author.google | Rivers, Charles | * |
dc.author.google | Shendre, Aditi | * |
dc.author.google | Dillon, Chrisly | * |
dc.author.google | Suriapranata, Ivet M. | * |
dc.author.google | Zhou, Hong-Hao | * |
dc.author.google | Tan, Sheng-Lan | * |
dc.author.google | Tatarunas, Vacis | * |
dc.author.google | Lesauskaite, Vaiva | * |
dc.author.google | Zhang, Yumao | * |
dc.author.google | Maitland-van der Zee, Anke H. | * |
dc.author.google | Verhoef, Talitha, I | * |
dc.author.google | de Boer, Anthonius | * |
dc.author.google | Taljaard, Monica | * |
dc.author.google | Zambon, Carlo Federico | * |
dc.author.google | Pengo, Vittorio | * |
dc.author.google | Zhang, Jieying Eunice | * |
dc.author.google | Pirmohamed, Munir | * |
dc.author.google | Johnson, Julie A. | * |
dc.author.google | Fava, Cristiano | * |
dc.date.modifydate | 20240422115307 | * |