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Phyto-fabrication of silver nanoparticles by Acacia nilotica leaves: Investigating their antineoplastic, free radical scavenging potential and application in H2O2 sensing

Title
Phyto-fabrication of silver nanoparticles by Acacia nilotica leaves: Investigating their antineoplastic, free radical scavenging potential and application in H2O2 sensing
Authors
Saratale, Rijuta GaneshSaratale, Ganesh DattatrayaCho, Si-KyungGhodake, GajananKadam, AvinashKumar, SunilMulla, Sikandar I.Kim, Dong-SuJeon, Byong-HunChang, Jo ShuShin, Han-Seung
Ewha Authors
김동수
SCOPUS Author ID
김동수scopus
Issue Date
2019
Journal Title
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
ISSN
1876-1070JCR Link

1876-1089JCR Link
Citation
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS vol. 99, pp. 239 - 249
Keywords
Acacia niloticaGreen synthesisSKOV3 ovarian cancer cellsAntibacterial activityH2O2 sensingFree radical scavenging activity
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
In this study, a green approach by utilizing Acacia nilotica leaves (ANL) extract to produce silver nanoparticles (AgNPs) has been made. The biosynthesized AgNPs displayed surface plasmon resonance (SPR) centered at 430 nm. Fourier transform infrared spectroscopy (FTIR) and energy-dispersive spectra (EDS) results showed the contribution of phyto-constituents of ANL in the reduction, capping and stabilizing matrix for AgNPs. The AgNPs were characterized by X-ray diffraction (XRD), and high resolution transmission electron microscopy (HR-TEM) revealed the synthesized ANL-AgNPs were crystalline and spherical forms having about 20 nm average particle size. ANL-AgNPs exhibited significant antineoplastic efficacy towards SKOV3 ovarian cancer cells (LD50; 66.5 mu g/mL) thus could be useful to treat the cancer and to trounce limitations of conventional chemotherapy treatment. The synthesized AgNPs unveiled substantial antioxidant activity represented by common enzyme markers 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) (IC50; 48.4 mu g/mL) and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) (IC50; 55.2 mu g/mL) activity. The ANL-AgNPs displayed substantial anti-bacterial activity against human pathogenic bacterial strains and also studied their minimum inhibitory and minimum bactericidal concentration (MIC and MBC) for individual strain. Additionally, the synthesized ANL-AgNPs exhibited colorimetric detection of hydrogen peroxide (H2O2) with better selectivity which showed its viability in determining reactive oxygen species in biological and environmental samples. Overall, the ANL-AgNPs could be used in multi-tasking biomedical applications, including anticancer, antioxidant, and antibacterial potential and also in sensing application. (C) 2019 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
DOI
10.1016/j.jtice.2019.03.003
Appears in Collections:
엘텍공과대학 > 환경공학전공 > Journal papers
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