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In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery

Title
In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery
Authors
Park, SuehyunSong, JeongeunKim, Jun Soo
Ewha Authors
김준수
SCOPUS Author ID
김준수scopus
Issue Date
2019
Journal Title
SCIENCE ADVANCES
ISSN
2375-2548JCR Link
Citation
SCIENCE ADVANCES vol. 5, no. 4
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Brownian particles confined in a system with periodic and asymmetric potential can be transported in a specific direction along the potential by repetitively switching the potential on and off. Here, we propose a DNA-based Brownian ratchet for directional transport of positively charged nanoparticles in which nanoparticle delivery follows the path dictated by a single, long, double-stranded DNA. We performed Brownian dynamics simulations to prove its realization using coarse-grained models. A periodic and asymmetric potential for nanoparticle binding is constructed along a single, long, double-stranded DNA molecule by a novel strategy that uses variation in sequence-dependent DNA flexibility. Directional and processive motion of nanoparticles is achieved by changing salt concentration repetitively over several cycles to switch the asymmetric potential on and off. This work suggests that double-stranded DNA molecules with elaborately designed flexibility variation can be used as a molecule-scale guide for spatial and dynamic control of nanoparticles for future applications.
DOI
10.1126/sciadv.aav4943
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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