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Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-alpha-Induced Apoptosis via Different Routes

Title
Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-alpha-Induced Apoptosis via Different Routes
Authors
Lee, SunmiLee, Joo YoungLee, Eun WooPark, SujinKang, Dong HoonMin, ChengchunLee, Doo JaeKang, DongminSong, JaewhanKwon, JongbumKang, Sang Won
Ewha Authors
강상원권종범강동민이두재강동훈Min Chengchun
SCOPUS Author ID
강상원scopus; 권종범scopus; 강동민scopus; 이두재scopus; 강동훈scopus
Issue Date
2019
Journal Title
CELL REPORTS
ISSN
2211-1247JCR Link
Citation
CELL REPORTS vol. 26, no. 8, pp. 2194 - +
Publisher
CELL PRESS
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
There are abundant peroxiredoxin (Prx) enzymes, but an increase of cellular H2O2 level always happens in apoptotic cells. Here, we show that cellular H2O2 switches different apoptosis pathways depending on which type of Prx enzyme is absent. TNF alpha-induced H2O2 burst preferentially activates the DNA damage-dependent apoptosis pathway in the absence of PrxI. By contrast, the same H2O2 burst stimulates the RIPK1-dependent apoptosis pathway in the absence of PrxII by inducing the destruction of cIAP1 in caveolar membrane. Specifically, H2O2 induces the oxidation of Cys308 residue in the cIAP1-BIR3 domain, which induces the dimerization-dependent E3 ligase activation. Thus, the reduction in cIAP level by the absence of PrxII triggers cell-autonomous apoptosis in cancer cells and tumors. Such differential functions of PrxI and PrxII are mediated by interaction with H2AX and cIAP1, respectively. Collectively, this study reveals the distinct switch roles of 2-Cys Prx isoforms in apoptosis signaling.
DOI
10.1016/j.celrep.2019.01.081
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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