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Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-

Title
Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-
Authors
Kim W.-K.Choi Y.-B.Rayudu P.V.Das P.Asaad W.Arnelle D.R.Stamler J.S.Lipton S.A.
Ewha Authors
김원기
Issue Date
1999
Journal Title
Neuron
ISSN
0896-6273JCR Link
Citation
Neuron vol. 24, no. 2, pp. 461 - 469
Indexed
SCI; SCIE; SCOPUS scopus
Document Type
Article
Abstract
Recent evidence indicates that the NO-related species, nitroxyl anion (NO-), is produced in physiological systems by several redox metal- containing proteins, including hemoglobin, nitric oxide synthase (NOS), superoxide dismutase, and S-nitrosothiols (SNOs), which have recently been identified in brain. However, the chemical biology of NO- remains largely unknown. Here, we show that NO- - unlike NO-, but reminiscent of NO+ transfer (or S-nitrosylation) - reacts mainly with Cys-399 in the NR2A subunit of the N-methyl-D-aspartate (NMDA) receptor to curtail excessive CA2+ influx and thus provide neuroprotection from excitotoxic insults. This effect of NO- closely resembles that of NOS, which also downregulates NMDA receptor activity under similar conditions in culture.
DOI
10.1016/S0896-6273(00)80859-4
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자연과학대학 > 화학·나노과학전공 > Journal papers
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