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Fluorogenic probes for disease-relevant enzymes

Title
Fluorogenic probes for disease-relevant enzymes
Authors
Zhang J.Chai X.He X.-P.Kim H.-J.Yoon J.Tian H.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2019
Journal Title
Chemical Society Reviews
ISSN
0306-0012JCR Link
Citation
Chemical Society Reviews vol. 48, no. 2, pp. 683 - 722
Publisher
Royal Society of Chemistry
Indexed
SCI; SCIE; SCOPUS scopus
Document Type
Review
Abstract
Traditional biochemical methods for enzyme detection are mainly based on antibody-based immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in particular, the in situ activity of enzymes in live cells and in vivo. In this review, we comprehensively summarize recent progress that has been made in the development of small-molecule as well as material-based fluorogenic probes for sensitive detection of the activities of enzymes that are related to a number of human diseases. The principles utilized to design these probes as well as their applications are reviewed. Specific attention is given to fluorogenic probes that have been developed for analysis of the activities of enzymes including oxidases and reductases, those that act on biomacromolecules including DNAs, proteins/peptides/amino acids, carbohydrates and lipids, and those that are responsible for translational modifications. We envision that this review will serve as an ideal reference for practitioners as well as beginners in relevant research fields. © The Royal Society of Chemistry.
DOI
10.1039/c7cs00907k
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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