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Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts

Title
Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts
Authors
Bae, Sung-JinShin, Min WookSon, TaekwonLee, Hye ShinChae, Ji SooJeon, SejinOh, Goo TaegKim, Kyu-Won
Ewha Authors
오구택전세진
SCOPUS Author ID
오구택scopus
Issue Date
2019
Journal Title
EXPERIMENTAL AND MOLECULAR MEDICINE
ISSN
1226-3613JCR Link

2092-6413JCR Link
Citation
EXPERIMENTAL AND MOLECULAR MEDICINE vol. 51
Publisher
NATURE PUBLISHING GROUP
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Osteoclasts (OCs) are bone-resorbing cells that originate from hematopoietic stem cells and develop through the fusion of mononuclear myeloid precursors. Dysregulation of OC development causes bone disorders such as osteopetrosis, osteoporosis, and rheumatoid arthritis. Although the molecular mechanisms underlying osteoclastogenesis have been well established, the means by which OCs maintain their survival during OC development remain unknown. We found that Ninjurin1 (Ninj1) expression is dynamically regulated during osteoclastogenesis and that Ninj1(-/-) mice exhibit increased trabecular bone volume owing to impaired OC development. Ninj1 deficiency did not alter OC differentiation, transmigration, fusion, or actin ring formation but increased Caspase-9-dependent intrinsic apoptosis in prefusion OCs (preOCs). Overexpression of Ninj1 enhanced the survival of mouse macrophage/preOC RAW264.7 cells in osteoclastogenic culture, suggesting that Ninj1 is important for the survival of preOCs. Finally, analysis of publicly available microarray data sets revealed a potent correlation between high NINJ1 expression and destructive bone disorders in humans. Our data indicate that Ninj1 plays an important role in bone homeostasis by enhancing the survival of preOCs.
DOI
10.1038/s12276-018-0201-3
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자연과학대학 > 생명과학전공 > Journal papers
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