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A dynamic DNA nanostructure with switchable and size-selective molecular recognition properties

Title
A dynamic DNA nanostructure with switchable and size-selective molecular recognition properties
Authors
Kim, Chan-JinJeong, Eun HyeLee, HyukjinPark, So-Jung
Ewha Authors
이혁진박소정김찬진
SCOPUS Author ID
이혁진scopus; 박소정scopus; 김찬진scopus
Issue Date
2019
Journal Title
NANOSCALE
ISSN
2040-3364JCR Link

2040-3372JCR Link
Citation
NANOSCALE vol. 11, no. 5, pp. 2501 - 2509
Publisher
ROYAL SOC CHEMISTRY
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Herein, we report a dynamic DNA nanostructure exhibiting switchable and size-selective molecular recognition properties. A DNA block copolymer, polystyrene-b-DNA (PS-b-DNA), and a thermo-responsive block copolymer, PS-b-poly(N-isopropylacrylamide) (PS-b-PNIPAM), were simultaneously assembled to form hybrid micelles composed of a PS core and a DNA/PNIPAM corona. PNIPAM strands did not significantly hinder the binding of molecular DNA for a broad range of PNIPAM lengths. On the other hand, they exerted significant steric hindrance for interactions with nanoscale species, which can be reversibly turned off by increasing the temperature above the lower critical solution temperature (LCST) of PNIPAM. Owing to the switchable and size-selective steric hindrance, the hybrid DNA micelles showed thermally controllable enzymatic degradation and cellular uptake. These results demonstrate that the binary self-assembly of two different responsive block copolymers is a promising approach to prepare dynamic nanostructures with controllable biological recognition properties.
DOI
10.1039/c8nr09341e
Appears in Collections:
약학대학 > 약학과 > Journal papers
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