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dc.contributor.author이공주-
dc.contributor.author하헌주-
dc.date.accessioned2019-02-26T16:30:04Z-
dc.date.available2019-02-26T16:30:04Z-
dc.date.issued2019-
dc.identifier.issn2045-2322-
dc.identifier.otherOAK-24416-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/249383-
dc.description.abstractLong-term peritoneal dialysis is associated with progressive fibrosis of the peritoneum. Epithelial-mesenchymal transition (EMT) of mesothelial cells is an important mechanism involved in peritoneal fibrosis, and TGF-β1 is considered central in this process. However, targeting currently known TGF-β1-associated pathways has not proven effective to date. Therefore, there are still gaps in understanding the mechanisms underlying TGF-β1-associated EMT and peritoneal fibrosis. We conducted network-based integrated analysis of transcriptomic and proteomic data to systemically characterize the molecular signature of TGF-β1-stimulated human peritoneal mesothelial cells (HPMCs). To increase the power of the data, multiple expression datasets of TGF-β1-stimulated human cells were employed, and extended based on a human functional gene network. Dense network sub-modules enriched with differentially expressed genes by TGF-β1 stimulation were prioritized and genes of interest were selected for functional analysis in HPMCs. Through integrated analysis, ECM constituents and oxidative stress-related genes were shown to be the top-ranked genes as expected. Among top-ranked sub-modules, TNFAIP6, ZC3H12A, and NNT were validated in HPMCs to be involved in regulation of E-cadherin, ZO-1, fibronectin, and αSMA expression. The present data shows the validity of network-based integrated analysis in discovery of novel players in TGF-β1-induced EMT in peritoneal mesothelial cells, which may serve as new prognostic markers and therapeutic targets for peritoneal dialysis patients. © 2019, The Author(s).-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.titleNetwork-based integrated analysis of omics data reveal novel players of TGF-β1-induced EMT in human peritoneal mesothelial cells-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume9-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.journaltitleScientific Reports-
dc.identifier.doi10.1038/s41598-018-37101-9-
dc.identifier.scopusid2-s2.0-85061128664-
dc.author.googleHan S.M.-
dc.author.googleRyu H.-M.-
dc.author.googleSuh J.-
dc.author.googleLee K.-J.-
dc.author.googleChoi S.-Y.-
dc.author.googleChoi S.-
dc.author.googleKim Y.-L.-
dc.author.googleHuh J.Y.-
dc.author.googleHa H.-
dc.contributor.scopusid이공주(7501497635)-
dc.contributor.scopusid하헌주(7202277106)-
dc.date.modifydate20190502174229-


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