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In Vivo Albumin Traps Photosensitizer Monomers from Self-Assembled Phthalocyanine Nanovesicles: A Facile and Switchable Theranostic Approach
- Title
- In Vivo Albumin Traps Photosensitizer Monomers from Self-Assembled Phthalocyanine Nanovesicles: A Facile and Switchable Theranostic Approach
- Authors
- Li X.; Yu S.; Lee Y.; Guo T.; Kwon N.; Lee D.; Yeom S.C.; Cho Y.; Kim G.; Huang J.-D.; Choi S.; Nam K.T.; Yoon J.
- Ewha Authors
- 윤주영; 최선
- SCOPUS Author ID
- 윤주영; 최선
- Issue Date
- 2019
- Journal Title
- Journal of the American Chemical Society
- ISSN
- 0002-7863
- Citation
- Journal of the American Chemical Society vol. 141, no. 3, pp. 1366 - 1372
- Publisher
- American Chemical Society
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Albumin is a promising candidate as a biomarker for potential disease diagnostics and has been extensively used as a drug delivery carrier for decades. In these two directions, many albumin-detecting probes and exogenous albumin-based nanocomposite delivery systems have been developed. However, there are only a few cases demonstrating the specific interactions of exogenous probes with albumin in vivo, and nanocomposite delivery systems usually suffer from tedious fabrication processes and potential toxicity of the complexes. Herein, we demonstrate a facile "one-for-all" switchable nanotheranostic (NanoPcS) for both albumin detection and cancer treatment. In particular, the in vivo specific binding between albumin and PcS, arising from the disassembly of injected NanoPcS, is confirmed using an inducible transgenic mouse system. Fluorescence imaging and antitumor tests on different tumor models suggest that NanoPcS has superior tumor-targeting ability and the potential for time-modulated, activatable photodynamic therapy. © 2018 American Chemical Society.
- DOI
- 10.1021/jacs.8b12167
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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