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Proteogenomic Characterization of Human Early-Onset Gastric Cancer
- Proteogenomic Characterization of Human Early-Onset Gastric Cancer
- Mun D.-G.; Bhin J.; Kim S.; Kim H.; Jung J.H.; Jung Y.; Jang Y.E.; Park J.M.; Lee H.; Bae J.; Back S.; Kim S.-J.; Kim J.; Park H.; Li H.; Hwang K.-B.; Park Y.S.; Yook J.H.; Kim B.S.; Kwon S.Y.; Ryu S.W.; Park D.Y.; Jeon T.Y.; Kim D.H.; Lee J.-H.; Han S.-U.; Song K.S.; Park D.; Park J.W.; Rodriguez H.; Kim K.P.; Yang E.G.; Kim H.K.; Paek E.; Lee S.; Lee S.-W.; Hwang D.
- Ewha Authors
- 이상혁; 김재상
- SCOPUS Author ID
- 이상혁; 김재상
- Issue Date
- Journal Title
- Cancer Cell
- Cancer Cell vol. 35, no. 1, pp. 111 - 1.24E12
- cancer subtypes; correlation between mRNA and protein abundance changes; correlation between mutation and phosphorylation; diffuse gastric cancer; proteogenomics; somatic nonsynonymous mutations
- Cell Press
- SCI; SCIE; SCOPUS
- Document Type
- We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs. © 2018 Elsevier Inc.Mun et al. perform proteogenomic analysis of diffuse gastric cancers (DGC) in a young population, identifying that correlations of mRNA-protein abundance associate with survival and defining four subtypes of DGC. The associations of some subtypes with related pathways are identified mainly by the proteomic data. © 2018 Elsevier Inc.
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