View : 55 Download: 0

Proteogenomic Characterization of Human Early-Onset Gastric Cancer

Title
Proteogenomic Characterization of Human Early-Onset Gastric Cancer
Authors
Mun D.-G.Bhin J.Kim S.Kim H.Jung J.H.Jung Y.Jang Y.E.Park J.M.Lee H.Bae J.Back S.Kim S.-J.Kim J.Park H.Li H.Hwang K.-B.Park Y.S.Yook J.H.Kim B.S.Kwon S.Y.Ryu S.W.Park D.Y.Jeon T.Y.Kim D.H.Lee J.-H.Han S.-U.Song K.S.Park D.Park J.W.Rodriguez H.Kim K.P.Yang E.G.Kim H.K.Paek E.Lee S.Lee S.-W.Hwang D.
Ewha Authors
이상혁김재상
SCOPUS Author ID
이상혁scopus; 김재상scopus
Issue Date
2019
Journal Title
Cancer Cell
ISSN
1535-6108JCR Link
Citation
Cancer Cell vol. 35, no. 1, pp. 111 - 1.24E12
Keywords
cancer subtypescorrelation between mRNA and protein abundance changescorrelation between mutation and phosphorylationdiffuse gastric cancerproteogenomicssomatic nonsynonymous mutations
Publisher
Cell Press
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs. © 2018 Elsevier Inc.Mun et al. perform proteogenomic analysis of diffuse gastric cancers (DGC) in a young population, identifying that correlations of mRNA-protein abundance associate with survival and defining four subtypes of DGC. The associations of some subtypes with related pathways are identified mainly by the proteomic data. © 2018 Elsevier Inc.
DOI
10.1016/j.ccell.2018.12.003
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE