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Pharmacology of natural radioprotectors
- Title
- Pharmacology of natural radioprotectors
- Authors
- Mun, Gil-Im; Kim, Seoyoung; Choi, Eun; Kim, Cha Soon; Lee, Yun-Sil
- Ewha Authors
- 이윤실
- SCOPUS Author ID
- 이윤실
- Issue Date
- 2018
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- ISSN
- 0253-6269
1976-3786
- Citation
- ARCHIVES OF PHARMACAL RESEARCH vol. 41, no. 11, pp. 1033 - 1050
- Keywords
- Natural compounds; Toxicity; Mechanisms; Radioprotectors
- Publisher
- PHARMACEUTICAL SOC KOREA
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Review
- Abstract
- Radiotherapy is one of the most efficient ways to treat cancer. However, deleterious effects, such as acute and chronic toxicities that reduce the quality of life, may result. Naturally occurring compounds have been shown to be non-toxic over wide dose ranges and are inexpensive and effective. Additionally, pharmacological strategies have been developed that use radioprotectors to inhibit radiation-induced toxicities. Currently available radioprotectors have several limitations, including toxicity. In this review, we present the mechanisms of proven radioprotectors, ranging from free radical scavenging (the best-known mechanism of radioprotection) to molecular-based radioprotection (e.g., upregulating expression of heat shock proteins). Finally, we discuss naturally occurring compounds with radioprotective properties in the context of these mechanisms.
- DOI
- 10.1007/s12272-018-1083-6
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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