View : 104 Download: 13

Rpd3L HDAC links H3K4me3 to transcriptional repression memory

Title
Rpd3L HDAC links H3K4me3 to transcriptional repression memory
Authors
Lee, Bo BaeChoi, AhyoungKim, Ji HyunJun, YukyungWoo, HyeonjuHa, So DamYoon, Chae YoungHwang, Jin-TaekSteinmetz, LarsBuratowski, StephenLee, SanghyukKim, Hye YoungKim, TaeSoo
Ewha Authors
이상혁김태수
SCOPUS Author ID
이상혁scopus; 김태수scopus
Issue Date
2018
Journal Title
NUCLEIC ACIDS RESEARCH
ISSN
0305-1048JCR Link

1362-4962JCR Link
Citation
NUCLEIC ACIDS RESEARCH vol. 46, no. 16, pp. 8261 - 8274
Publisher
OXFORD UNIV PRESS
Indexed
SCI; SCIE; SCOPUS WOS
Document Type
Article
Abstract
Transcriptional memory is critical for the faster reactivation of necessary genes upon environmental changes and requires that the genes were previously in an active state. However, whether transcriptional repression also displays 'memory' of the prior transcriptionally inactive state remains unknown. In this study, we show that transcriptional repression of similar to 540 genes in yeast occurs much more rapidly if the genes have been previously repressed during carbon source shifts. This novel transcriptional response has been termed transcriptional repression memory (TREM). Interestingly, Rpd3L histone deacetylase (HDAC), targeted to active promoters induces TREM. Mutants for Rpd3L exhibit increased acetylation at active promoters and delay TREM significantly. Surprisingly, the interaction between H3K4me3 and Rpd3L via the Pho23 PHD finger is critical to promote histone deacetylation and TREM by Rpd3L. Therefore, we propose that an active mark, H3K4me3 enriched at active promoters, instructs Rpd3L HDAC to induce histone deacetylation and TREM.
DOI
10.1093/nar/gky573
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
Files in This Item:
Rpd3L HDAC links.pdf(2.34 MB) Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE