Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김길현 | - |
dc.date.accessioned | 2018-12-27T16:30:06Z | - |
dc.date.available | 2018-12-27T16:30:06Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 1225-8687 | - |
dc.identifier.other | OAK-17035 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247966 | - |
dc.description.abstract | Many cell types are known to stimulate CD8+ T cells in allogeneic recognition such as mixed lymphocyte reaction (MLR). Whereas dendritic cells are most potent among them, T cells are usually considered very poor in stimulating CD8+ T cells although there are some tumor cells that are weakly stimulatory. T cells, as a stimulator, cultured in the presence of concanavalin A that were otherwise nonstimulatory to CD8+ T cells appeared to stimulate CD8+ T cells strongly when they were pretreated with neuraminidase. The enhancement of MLR by neuraminidase could be achieved by treating either the stimulators or responders with neuraminidase. Removal of negatively-charged sialic acid moieties from the cell surface, which reduced electrostatic repulsion between responders and stimulators to give better cell-cell contact might be responsible for the enhanced MLR. In addition, neuraminidase treatment also appeared to deliver activation signal to responding T cells since it could activate CD8+ T cells in synergy with phorbol myristate acetate. The maximal responses were observed when both responders and stimulators were treated with neuraminidase. | - |
dc.language | English | - |
dc.title | Neuraminidase treatment enhances allogeneic stimulation of unprimed CD8+ T cells | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 30 | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 385 | - |
dc.relation.lastpage | 389 | - |
dc.relation.journaltitle | Journal of Biochemistry and Molecular Biology | - |
dc.identifier.scopusid | 2-s2.0-0031328387 | - |
dc.author.google | Kim K. | - |
dc.contributor.scopusid | 김길현(56092131700) | - |
dc.date.modifydate | 20211210152111 | - |