View : 46 Download: 0

Effect and interactions of Pueraria-Rehmannia and aerobic exercise on metabolic inflexibility and insulin resistance in ovariectomized rats fed with a high-fat diet

Title
Effect and interactions of Pueraria-Rehmannia and aerobic exercise on metabolic inflexibility and insulin resistance in ovariectomized rats fed with a high-fat diet
Authors
Kim Y.J.Kim H.J.Oak H.M.Jeong H.Y.Lee W.J.Weaver C.Kwon O.
Ewha Authors
이원준권오란
SCOPUS Author ID
이원준scopus; 권오란scopus
Issue Date
2018
Journal Title
Journal of Functional Foods
ISSN
1756-4646JCR Link
Citation
Journal of Functional Foods vol. 45, pp. 146 - 154
Keywords
Aerobic exerciseFoxgloveInsulin resistanceKudzu puerarinMetabolic inflexibilityOvariectomized rats
Publisher
Elsevier Ltd
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Due to limitations of estrogen replacement therapy, life style interventions have received a growing attention. This study aimed to determine whether Pueraria-Rehmannia (PR) and/or aerobic exercise (Ex) could reduce cardiometabolic dysfunction in an ovariectomized/high-fat diet rat model. PR ameliorated circulating levels of total cholesterol, LDL/HDL ratio, and leptin. It reduced fat mass, fat size, leptin gene expression, and macrophage infiltration in adipocytes. PR maintained leptin receptor gene expression in muscle tissues. It stimulated insulin-mediated GLUT4 translocation in muscle and adipose tissues. PR plus Ex resulted in further improvement in glucose homeostasis by stimulating Akt-mediated insulin receptor expression in the liver. Moreover, PR and/or Ex reduced vascular wall thickness and intracellular cell adhesion molecule-1 production without causing uterotrophic effect. These results suggest that PR and Ex may exert synergistic effects in modifying metabolic dysfunctions and insulin resistance, thus suppressing cardiovascular risks in postmenopausal women through restoring insulin sensitivity and attenuating inflammation. © 2018 Elsevier Ltd
DOI
10.1016/j.jff.2018.04.006
Appears in Collections:
신산업융합대학 > 체육과학부 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE