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Development and clinical application of an evidence-based pharmaceutical care service algorithm in acute coronary syndrome

Title
Development and clinical application of an evidence-based pharmaceutical care service algorithm in acute coronary syndrome
Authors
Kang, J. E.Yu, J. M.Choi, J. H.Chung, I. -M.Pyun, W. B.Kim, S. A.Lee, E. K.Han, N. Y.Yoon, J. -H.Oh, J. M.Rhie, S. J.
Ewha Authors
정익모편욱범이정연
SCOPUS Author ID
정익모scopus; 편욱범scopus; 이정연scopus
Issue Date
2018
Journal Title
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
ISSN
0269-4727JCR Link

1365-2710JCR Link
Citation
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS vol. 43, no. 3, pp. 366 - 376
Keywords
acute coronary syndromeevidence-based practicepharmaceutical careservice algorithm
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
What is known and objective: Drug therapies are critical for preventing secondary complications in acute coronary syndrome (ACS). The purpose of this study was to develop and apply a pharmaceutical care service (PCS) algorithm for ACS and confirm that it is applicable through a prospective clinical trial. Methods: The ACS-PCS algorithm was developed according to extant evidence-based treatment and pharmaceutical care guidelines. Quality assurance was conducted through two methods: literature comparison and expert panel evaluation. The literature comparison was used to compare the content of the algorithm with the referenced guidelines. Expert evaluations were conducted by nine experts for 75 questionnaire items. A trial was conducted to confirm its effectiveness. Seventy-nine patients were assigned to either the pharmacist-included multidisciplinary team care (MTC) group or the usual care (UC) group. The endpoints of the trial were the prescription rate of two important drugs, readmission, emergency room (ER) visit and mortality. Results and discussion: The main frame of the algorithm was structured with three tasks: medication reconciliation, medication optimization and transition of care. The contents and context of the algorithm were compliant with class I recommendations and the main service items from the evidence-based guidelines. Opinions from the expert panel were mostly positive. There were significant differences in beta-blocker prescription rates in the overall period (P=.013) and ER visits (four cases, 9.76%, P=.016) in the MTC group compared to the UC group, respectively. What is new and conclusion: We developed a PCS algorithm for ACS based on the contents of evidence-based drug therapy and the core concept of pharmacist services.
DOI
10.1111/jcpt.12665
Appears in Collections:
약학대학 > 약학과 > Journal papers
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