View : 21 Download: 0

Factors affecting time to reach and recover from gefitinib-induced hepatotoxicity

Title
Factors affecting time to reach and recover from gefitinib-induced hepatotoxicity
Authors
Park Y.H.Cho S.Yee J.Kim J.Y.Rhie S.J.Gwak H.S.
Ewha Authors
곽혜선이정연
SCOPUS Author ID
곽혜선scopus; 이정연scopus
Issue Date
2018
Journal Title
Anti-Cancer Drugs
ISSN
0959-4973JCR Link
Citation
Anti-Cancer Drugs vol. 29, no. 5, pp. 471 - 476
Keywords
GefitinibHepatotoxicityTime to reach hepatotoxicityTime to recover from hepatotoxicity
Publisher
Lippincott Williams and Wilkins
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Gefitinib is an oral tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR) for non-small-cell lung cancer with EGFR mutations. Although a few studies have analyzed the causes of gefitinib-induced hepatotoxicity, research focusing on the time intervals before and after hepatotoxicity has yet to be reported. Therefore, this study investigated two types of factors: the time to reach gefitinib-induced hepatotoxicity and the time for recovery. From January 2013 to December 2014, a retrospective study was carried out on 473 non-small-cell lung cancer patients who were treated with gefitinib. The following data were collected: sex, age, body weight, height, body surface area, underlying disease, Eastern Cooperative Oncology Group Performance Status, smoking history, gefitinib dose, EGFR mutation, and concomitant drugs. Multivariate models showed that patients with mutations in exon 19 had around two-fold higher hepatotoxicity (=grade 2). Use of CYP3A4 inhibitors and smoking shortened time to hepatotoxicity ~5-2-fold, respectively, whereas mutations in exon 21 prolonged time to hepatotoxicity by about 2.4-fold. Termination of gefitinib therapy showed 3.8-fold faster recovery. Our study showed that the concomitant use of CYP3A4 inhibitors, smoking, and exon 21 affected the time to reach gefitinib-induced hepatotoxicity. Among the factors examined in this study including hepatotonic use and gefitinib termination, only cessation of gefitinib therapy significantly accelerated recovery. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
DOI
10.1097/CAD.0000000000000622
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE