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Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice

Title
Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice
Authors
Kim S.-N.Akindehin S.Kwon H.-J.Son Y.-H.Saha A.Jung Y.-S.Seong J.-K.Lim K.-M.Sung J.-H.Maddipati K.R.Lee Y.-H.
Ewha Authors
임경민
SCOPUS Author ID
임경민scopus
Issue Date
2018
Journal Title
Scientific Reports
ISSN
2045-2322JCR Link
Citation
Scientific Reports vol. 8, no. 1
Publisher
Nature Publishing Group
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
15-lipoxygenase is involved in the generation of specialized pro-resolving lipid mediators that play essential roles in resolution and inflammatory responses. Here, we investigated anti-inflammatory role of Alox15 in skin homeostasis. We demonstrated that knockout (KO) of Alox15 led to hair loss and disrupted the structural integrity of the dorsal skin. Alox15 KO resulted in loss of hair follicle stem cells and abnormal transition of dermal adipocytes into fibroblasts. Alox15 deficiency increased infiltration of proinflammatory macrophages and upregulated proinflammatory and necroptotic signaling in dermal adipose tissue in the dorsal skin. Lipidomic analysis revealed severe loss of resolvin D2 in the dorsal skin of Alox15 KO mice compared to wild type controls. Treatment with resolvin D2 reduced skin inflammation in Alox15 KO mice. Collectively, these results indicate that Alox15-mediated production of resolvin D2 is required to maintain skin integrity by suppressing dermal inflammation. © 2018 The Author(s).
DOI
10.1038/s41598-018-27221-7
Appears in Collections:
약학대학 > 약학과 > Journal papers
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