Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 최진호 | - |
dc.contributor.author | 최고은 | - |
dc.date.accessioned | 2018-12-14T16:30:52Z | - |
dc.date.available | 2018-12-14T16:30:52Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.other | OAK-22631 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247729 | - |
dc.description.abstract | An attempt is made to apply layered double hydroxide (LDH) as a boron delivery carrier for boron neutron capture therapy (BNCT), which needs a sufficient amount of boron in tumor cells for its successful administration. To meet this requirement, a nanohybrid (BSH-LDH), mercaptoundecahydro-closo-dodecaborate (BSH) anionic molecules in LDH, is developed as a boron delivery system. The cellular boron content upon permeation of BSH-LDH nanoparticles (42.4 µg 10B 10−6 cells) in U87 glioblastoma cell line is found to be ≈2000 times larger than the minimum boron requirement (≈0.02 µg 10B 10−6 cells) for BNCT and also orders of magnitude higher than the previous results (0.2–1.5 µg 10B 10−6 cells) by those applied with other targeting strategies, and eventually results in excellent neutron capture efficiency even under such low dose (30 µg 10B mL−1) and weak irradiation (1 × 1012 n cm−2 corresponding to 20 min) condition. According to the biodistribution studies in xenograft mice model, the tumor-to-blood ratio of BSH in the BSH-LDH-treated-group is found to be 4.4-fold higher than that in the intact BSH treated one in 2 h after drug treatment. The present BNCT combined with boron delivery system provides a promising integrative therapeutic platform for cancer treatment. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.description.sponsorship | National Research Foundation of Korea | - |
dc.language | English | - |
dc.publisher | Wiley-VCH Verlag | - |
dc.subject | bioinorganic nanohybrids | - |
dc.subject | boron delivery | - |
dc.subject | boron neutron capture therapy | - |
dc.subject | nanovehicles | - |
dc.title | Highly Condensed Boron Cage Cluster Anions in 2D Carrier and Its Enhanced Antitumor Efficiency for Boron Neutron Capture Therapy | - |
dc.type | Article | - |
dc.relation.issue | 27 | - |
dc.relation.volume | 28 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | Advanced Functional Materials | - |
dc.identifier.doi | 10.1002/adfm.201704470 | - |
dc.identifier.wosid | WOS:000436929400017 | - |
dc.identifier.scopusid | 2-s2.0-85033212331 | - |
dc.author.google | Choi G. | - |
dc.author.google | Jeon I.-R. | - |
dc.author.google | Piao H. | - |
dc.author.google | Choy J.-H. | - |
dc.contributor.scopusid | 최진호(8044393000) | - |
dc.contributor.scopusid | 최고은(36622874700) | - |
dc.date.modifydate | 20220412094721 | - |