Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유충규 | - |
dc.date.accessioned | 2018-12-14T16:30:49Z | - |
dc.date.available | 2018-12-14T16:30:49Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.other | OAK-22650 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247711 | - |
dc.description.abstract | Picornaviruses are non-enveloped viruses that represent a large family of positive-sense single-stranded RNA viruses including a number of causative agents of many human and animal diseases such as coxsackievirus B3 (CVB3) and rhinoviruses (HRV). In this study, we performed a high-throughput screening of a compound library composed of ∼6000 small molecules in search of potential picornavirus 3C protease (3Cpro) inhibitors. As results, we identified quinone analogues that effectively inhibited both CVB3 3Cpro and HRV 3Cpro with IC50 values in low micromolar range. Together with predicted binding modes of these compounds to the active site of the viral protease, it is implied that structural features of these non-peptidic inhibitors may act as useful scaffold for further anti-picornavirus drug design and development. © 2018 Elsevier Ltd | - |
dc.description.sponsorship | Korea Research Institute of Chemical Technology | - |
dc.language | English | - |
dc.publisher | Elsevier Ltd | - |
dc.subject | 3C protease inhibitors | - |
dc.subject | Antivirals | - |
dc.subject | Coxsackievirus B3 | - |
dc.subject | Picornavirus | - |
dc.title | Identification of quinone analogues as potential inhibitors of picornavirus 3C protease in vitro | - |
dc.type | Article | - |
dc.relation.issue | 14 | - |
dc.relation.volume | 28 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2533 | - |
dc.relation.lastpage | 2538 | - |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry Letters | - |
dc.identifier.doi | 10.1016/j.bmcl.2018.05.046 | - |
dc.identifier.wosid | WOS:000438467200036 | - |
dc.identifier.scopusid | 2-s2.0-85047821067 | - |
dc.author.google | Jung E. | - |
dc.author.google | Lee J.-Y. | - |
dc.author.google | Kim H.J. | - |
dc.author.google | Ryu C.-K. | - |
dc.author.google | Lee K.-I. | - |
dc.author.google | Kim M. | - |
dc.author.google | Lee C.-K. | - |
dc.author.google | Go Y.Y. | - |
dc.contributor.scopusid | 유충규(15846918400) | - |
dc.date.modifydate | 20210915133309 | - |