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Design and applications of fluorescent detectors for peroxynitrite

Title
Design and applications of fluorescent detectors for peroxynitrite
Authors
Wang, ShanChen, LiyanJangili, ParameshSharma, AmitLi, WeiHou, Ji-TingQin, CaiqinYoon, JuyoungKim, Jong Seung
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2018
Journal Title
COORDINATION CHEMISTRY REVIEWS
ISSN
0010-8545JCR Link

1873-3840JCR Link
Citation
COORDINATION CHEMISTRY REVIEWS vol. 374, pp. 36 - 54
Keywords
Fluorescence probesPeroxynitriteBoronic acids or boronatesN-dearylationIntracellular imagingIn vivo imagingReactive oxygen species (ROS)
Publisher
ELSEVIER SCIENCE SA
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Peroxynitrite (ONOO-) is one of the endogenous reactive oxygen species (ROS), which causes damage to a wide array of molecular components in the cells, including DNA and proteins, owing to its high oxidizing as well as nitrating properties. However, the precise pathogenic roles played by this substance in biological systems have not yet been elucidated completely owing to its short lifetime, high reactivity, low concentration and elusive nature in the in vivo applications. Thus, the development of more sensitive and selective techniques for detecting ONOO-, with high biocompatibilities, sensitivities, and site specificities, is a significant goal. This review summarizes the recent advances that have been made in developing fluorescent sensors for ONOO- and their biological applications in diverse living systems. (C) 2018 Elsevier B.V. All rights reserved
DOI
10.1016/j.ccr.2018.06.013
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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