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Depsidomycins B and C: New cyclic peptides from a ginseng farm soil-derived actinomycete
- Title
- Depsidomycins B and C: New cyclic peptides from a ginseng farm soil-derived actinomycete
- Authors
- Kwon Y.; Byun W.S.; Kim B.-Y.; Song M.C.; Bae M.; Yoon Y.J.; Shin J.; Lee S.K.; Oh D.-C.
- Ewha Authors
- 윤여준; 송명종
- SCOPUS Author ID
- 윤여준
; 송명종![scopus](/images/layout/icon2.png)
- Issue Date
- 2018
- Journal Title
- Molecules
- ISSN
- 1420-3049
- Citation
- Molecules vol. 23, no. 6
- Keywords
- Actinomycete; Antimetastatic; Cyclic peptide; Farm soil; Streptomyces sp.
- Publisher
- MDPI AG
- Indexed
- SCIE; SCOPUS
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- LC/MS-based chemical profiling of a ginseng farm soil-derived actinomycete strain, Streptomyces sp. BYK1371, enabled the discovery of two new cyclic heptapeptides, depsidomycins B and C (1 and 2), each containing two piperazic acid units and a formyl group at their N-terminus. The structures of 1 and 2 were elucidated by a combination of spectroscopic and chemical analyses. These new compounds were determined to possess D-leucine, D-threonine, D-valine, and S-piperazic acid based on the advanced Marfey’s method and a GITC (2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate) derivatization of their hydrolysates, followed by LC/MS analysis. Depsidomycins B and C displayed significant antimetastatic activities against metastatic breast cancer cells (MDA-MB-231). © 2018 by the authors.
- DOI
- 10.3390/molecules23061266
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
- Files in This Item:
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Depsidomycins B and C.pdf(1.65 MB)
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