Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이공주 | * |
dc.contributor.author | 서은경 | * |
dc.contributor.author | 신동해 | * |
dc.date.accessioned | 2018-12-14T16:30:37Z | - |
dc.date.available | 2018-12-14T16:30:37Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-22778 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247640 | - |
dc.description.abstract | Nm23-H1/NDPK-A is a tumor metastasis suppressor having NDP kinase (NDPK) activity. Nm23-H1 is positively associated with prolonged disease-free survival and good prognosis of cancer patients. Approaches to increasing the cellular levels of Nm23-H1 therefore have significance in the therapy of metastatic cancers. We found a small molecule, (+/-)-trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl] cyclohex-1-ene, that activates Nm23, hereafter called NMac1. NMac1 directly binds to Nm23-H1 and increases its NDPK activity. Employing various NMac1 derivatives and hydrogen/deuterium mass spectrometry (HDX-MS), we identified the pharmacophore and mode of action of NMac1. We found that NMac1 binds to the C-terminal of Nm23-H1 and induces the NDPK activation through its allosteric conformational changes. NMac1-treated MDA-MB-231 breast cancer cells showed dramatic changes in morphology and actin-cytoskeletal organization following inhibition of Rac1 activation. NMac1 also suppressed invasion and migration in vitro, and metastasis in vivo, in a breast cancer mouse model. NMac1 as an activator of NDPK has potential as an anti-metastatic agent. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | Small molecule activator of Nm23/NDPK as an inhibitor of metastasis | * |
dc.type | Article | * |
dc.relation.volume | 8 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | SCIENTIFIC REPORTS | * |
dc.identifier.doi | 10.1038/s41598-018-29101-6 | * |
dc.identifier.wosid | WOS:000439101600008 | * |
dc.identifier.scopusid | 2-s2.0-85050625065 | * |
dc.author.google | Lee, Jae-Jin | * |
dc.author.google | Kim, Hwang Suk | * |
dc.author.google | Lee, Ji-Sun | * |
dc.author.google | Park, Jimin | * |
dc.author.google | Shin, Sang Chul | * |
dc.author.google | Song, Soonwha | * |
dc.author.google | Lee, Eunsun | * |
dc.author.google | Choi, Jung-Eun | * |
dc.author.google | Suh, Ji-Wan | * |
dc.author.google | Lee, Hongsoo | * |
dc.author.google | Kim, Eunice EunKyeong | * |
dc.author.google | Seo, Eun Kyoung | * |
dc.author.google | Shin, Dong Hae | * |
dc.author.google | Lee, Ho-Young | * |
dc.author.google | Lee, Hee-Yoon | * |
dc.author.google | Lee, Kong-Joo | * |
dc.contributor.scopusid | 이공주(7501497635;57191532162) | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 신동해(57217374185) | * |
dc.date.modifydate | 20240118144717 | * |