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Phthalocyanine-Assembled Nanodots as Photosensitizers for Highly Efficient Type I Photoreactions in Photodynamic Therapy

Title
Phthalocyanine-Assembled Nanodots as Photosensitizers for Highly Efficient Type I Photoreactions in Photodynamic Therapy
Authors
Li X.Lee D.Huang J.-D.Yoon J.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2018
Journal Title
Angewandte Chemie - International Edition
ISSN
1433-7851JCR Link
Citation
Angewandte Chemie - International Edition vol. 57, no. 31, pp. 9885 - 9890
Keywords
nanodotsphotodynamic therapyphthalocyaninereactive oxygen speciestype I photoreactions
Publisher
Wiley-VCH Verlag
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Owing to their unique, nanoscale related optical properties, nanostructures assembled from molecular photosensitizers (PSs) have interesting applications in phototheranostics. However, most nanostructured PS assemblies are super-quenched, thus, preventing their use in photodynamic therapy (PDT). Although some of these materials undergo stimuli-responsive disassembly, which leads to partial recovery of PDT activity, their therapeutic potentials are unsatisfactory owing to a limited ability to promote generation reactive oxygen species (ROS), especially via type I photoreactions (i.e., not by 1O2 generation). Herein we demonstrate that a new, nanostructured phthalocyanine assembly, NanoPcA, has the ability to promote highly efficient ROS generation via the type I mechanism. The results of antibacterial studies demonstrate that NanoPcA has potential PDT applications. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI
10.1002/anie.201806551
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자연과학대학 > 화학·나노과학전공 > Journal papers
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