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Phthalocyanine-Assembled Nanodots as Photosensitizers for Highly Efficient Type I Photoreactions in Photodynamic Therapy
- Phthalocyanine-Assembled Nanodots as Photosensitizers for Highly Efficient Type I Photoreactions in Photodynamic Therapy
- Li X.; Lee D.; Huang J.-D.; Yoon J.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Angewandte Chemie - International Edition
- Angewandte Chemie - International Edition vol. 57, no. 31, pp. 9885 - 9890
- nanodots; photodynamic therapy; phthalocyanine; reactive oxygen species; type I photoreactions
- Wiley-VCH Verlag
- SCIE; SCOPUS
- Document Type
- Owing to their unique, nanoscale related optical properties, nanostructures assembled from molecular photosensitizers (PSs) have interesting applications in phototheranostics. However, most nanostructured PS assemblies are super-quenched, thus, preventing their use in photodynamic therapy (PDT). Although some of these materials undergo stimuli-responsive disassembly, which leads to partial recovery of PDT activity, their therapeutic potentials are unsatisfactory owing to a limited ability to promote generation reactive oxygen species (ROS), especially via type I photoreactions (i.e., not by 1O2 generation). Herein we demonstrate that a new, nanostructured phthalocyanine assembly, NanoPcA, has the ability to promote highly efficient ROS generation via the type I mechanism. The results of antibacterial studies demonstrate that NanoPcA has potential PDT applications. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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