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Ratiometric Two-Photon Fluorescent Probe for Detecting and Imaging Hypochlorite
- Title
- Ratiometric Two-Photon Fluorescent Probe for Detecting and Imaging Hypochlorite
- Authors
- Pak, Yen Leng; Park, Sang Jun; Xu, Qingling; Kim, Hwan Myung; Yoon, Juyoung
- Ewha Authors
- 윤주영
- SCOPUS Author ID
- 윤주영
- Issue Date
- 2018
- Journal Title
- ANALYTICAL CHEMISTRY
- ISSN
- 0003-2700
1520-6882
- Citation
- ANALYTICAL CHEMISTRY vol. 90, no. 15, pp. 9510 - 9514
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The ratiometric fluorescent probe B6S, which contains pyrene as a fluorophore and imidazoline-2-thione as a reactive site, was developed for detection of hypochlorite (OCl-). B6S displays a high specificity toward OCl(- )in contrast to other reactive oxygen species and reactive nitrogen species. The probe has a low detection limit and operates under biological conditions. Moreover, the low cytotoxicity of B6S enables it to be utilized effectively for OCl- imaging in living cells and tissues by using two-photon microscopy. The findings indicate that B6S has the capability of serving as a probe to explore the biological functions of OCl- in living systems.
- DOI
- 10.1021/acs.analchem.8b02195
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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