Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최혜영 | * |
dc.contributor.author | 최유원 | * |
dc.contributor.author | 변지연 | * |
dc.date.accessioned | 2018-12-14T16:30:18Z | - |
dc.date.available | 2018-12-14T16:30:18Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 0906-6705 | * |
dc.identifier.issn | 1600-0625 | * |
dc.identifier.other | OAK-22945 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247543 | - |
dc.description.abstract | Rosacea is one of the most common dermatoses of adults. Although the detailed pathophysiology remains unknown, it is thought that rosacea is caused by a consistently aberrant, innate immune response, and that LL-37 plays an important role. However, involvement of the inflammatory cytokine IL-33 has not yet been studied. We explored the role played by IL-33 in the pathophysiology of rosacea. First, we immunohistochemically evaluated the expression of IL-33 and its receptor (ST2) in rosacea skin. Second, we exposed HaCaT cells to ultraviolet B (UVB) irradiation in the presence or absence of LL-37 and measured the expression of proinflammatory cytokines including IL-33. We also analysed VEGF (vascular endothelial growth factor) mRNA expression and protein release after costimulation of HaCaT cells by LL-37 and IL-33. Immunohistochemically, IL-33 expression was enhanced in the skin of rosacea patients, especially with erythematotelangiectatic subtype. In vitro, UVB and LL-37 synergistically increased mRNAs expression of proinflammatory cytokines, especially IL-33 and IL-1. IL-33 protein release was also synergistically increased by LL-37 and UVB treatment. LL-37 and IL-33 stimulated VEGF mRNA expression and VEGF release from HaCaT cells. Our findings suggest that rosacea skin with abundant LL-37 may robustly produce and release IL-33 when exposed to UV radiation. IL-33 may participate in the angiogenesis and vasodilation of rosacea skin by enhancing VEGF release. | * |
dc.language | English | * |
dc.publisher | WILEY | * |
dc.subject | cathelicidin | * |
dc.subject | IL-33 | * |
dc.subject | LL-37 | * |
dc.subject | rosacea | * |
dc.subject | ultraviolet B | * |
dc.subject | vascular endothelial growth factor | * |
dc.title | Increased expression of IL-33 in rosacea skin and UVB-irradiated and LL-37-treated HaCaT cells | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 27 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1023 | * |
dc.relation.lastpage | 1029 | * |
dc.relation.journaltitle | EXPERIMENTAL DERMATOLOGY | * |
dc.identifier.doi | 10.1111/exd.13702 | * |
dc.identifier.wosid | WOS:000442988300012 | * |
dc.identifier.scopusid | 2-s2.0-85050345946 | * |
dc.author.google | Suhng, Eunah | * |
dc.author.google | Kim, Bo Hee | * |
dc.author.google | Choi, You Won | * |
dc.author.google | Choi, Hae Young | * |
dc.author.google | Cho, Hyunjin | * |
dc.author.google | Byun, Ji Yeon | * |
dc.contributor.scopusid | 최혜영(55724363200) | * |
dc.contributor.scopusid | 최유원(7404777738) | * |
dc.contributor.scopusid | 변지연(15724462400) | * |
dc.date.modifydate | 20240222131101 | * |