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Long-term effects of the SLC2A9 G844A and SLC22A12 C246T variants on serum uric acid concentrations in children

Title
Long-term effects of the SLC2A9 G844A and SLC22A12 C246T variants on serum uric acid concentrations in children
Authors
Lee, Hye AhPark, Bo HyunPark, Eun AeCho, Su JinKim, Hae SoonPark, Hyesook
Ewha Authors
박은애김혜순박혜숙조수진박보현이혜아
SCOPUS Author ID
박은애scopus; 김혜순scopus; 박혜숙scopus; 조수진scopus; 박보현scopus; 이혜아scopus
Issue Date
2018
Journal Title
BMC PEDIATRICS
ISSN
1471-2431JCR Link
Citation
BMC PEDIATRICS vol. 18
Keywords
ChildrenLongitudinal studyUrate transporter 1Uric acid
Publisher
BMC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background: We evaluated the effects of two single-nucleotide polymorphisms on UA concentrations in the first decade of life using repeated-measures data. Methods: We included all subjects who were followed-up at least once and for whom we had both UA and genotypic data (i.e., 375, 204, 307, and 363 patients aged 3, 5, 7, and 9 years, respectively). All participated in the Ewha Birth and Growth Cohort study. We used a mixed model analysis to estimate the longitudinal association of serum UA concentration due to the rs3825017 (SLC22A12 c. 246C > T) and rs16890979 (SLC2A9 c. 844G > A) genotypes. Results: Overall, the tracking coefficient of UA concentrations in children 3 to 9 years of age was 0.31, and was higher in boys than in girls (0.34 vs. 0.29, respectively). Regarding individual variance, serum UA concentrations decreased as age increased (beta = -0.07, p < 0.05), but there were no significant differences by sex. The effects of rs3825017 on UA concentration were significant in boys, but not in girls. Boys with the T allele of rs3825017 had higher concentrations than their counterparts regardless of the time of follow-up. The rs16890979 genotypes were not significantly associated with serum UA concentration in either sex. Conclusion: This study showed that rs3825017 in the SLC22A12 gene was associated with UA concentration in childhood.
DOI
10.1186/s12887-018-1272-y
Appears in Collections:
의과대학 > 의학과 > Journal papers
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