Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박은애 | * |
dc.contributor.author | 김혜순 | * |
dc.contributor.author | 박혜숙 | * |
dc.contributor.author | 조수진 | * |
dc.contributor.author | 박보현 | * |
dc.contributor.author | 이혜아 | * |
dc.date.accessioned | 2018-12-14T16:30:13Z | - |
dc.date.available | 2018-12-14T16:30:13Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1471-2431 | * |
dc.identifier.other | OAK-22972 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247520 | - |
dc.description.abstract | Background: We evaluated the effects of two single-nucleotide polymorphisms on UA concentrations in the first decade of life using repeated-measures data. Methods: We included all subjects who were followed-up at least once and for whom we had both UA and genotypic data (i.e., 375, 204, 307, and 363 patients aged 3, 5, 7, and 9 years, respectively). All participated in the Ewha Birth and Growth Cohort study. We used a mixed model analysis to estimate the longitudinal association of serum UA concentration due to the rs3825017 (SLC22A12 c. 246C > T) and rs16890979 (SLC2A9 c. 844G > A) genotypes. Results: Overall, the tracking coefficient of UA concentrations in children 3 to 9 years of age was 0.31, and was higher in boys than in girls (0.34 vs. 0.29, respectively). Regarding individual variance, serum UA concentrations decreased as age increased (beta = -0.07, p < 0.05), but there were no significant differences by sex. The effects of rs3825017 on UA concentration were significant in boys, but not in girls. Boys with the T allele of rs3825017 had higher concentrations than their counterparts regardless of the time of follow-up. The rs16890979 genotypes were not significantly associated with serum UA concentration in either sex. Conclusion: This study showed that rs3825017 in the SLC22A12 gene was associated with UA concentration in childhood. | * |
dc.language | English | * |
dc.publisher | BMC | * |
dc.subject | Children | * |
dc.subject | Longitudinal study | * |
dc.subject | Urate transporter 1 | * |
dc.subject | Uric acid | * |
dc.title | Long-term effects of the SLC2A9 G844A and SLC22A12 C246T variants on serum uric acid concentrations in children | * |
dc.type | Article | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | BMC PEDIATRICS | * |
dc.identifier.doi | 10.1186/s12887-018-1272-y | * |
dc.identifier.wosid | WOS:000443981400001 | * |
dc.identifier.scopusid | 2-s2.0-85052934864 | * |
dc.author.google | Lee, Hye Ah | * |
dc.author.google | Park, Bo Hyun | * |
dc.author.google | Park, Eun Ae | * |
dc.author.google | Cho, Su Jin | * |
dc.author.google | Kim, Hae Soon | * |
dc.author.google | Park, Hyesook | * |
dc.contributor.scopusid | 박은애(14424551500) | * |
dc.contributor.scopusid | 김혜순(55663596500) | * |
dc.contributor.scopusid | 박혜숙(57201862679;56148186100) | * |
dc.contributor.scopusid | 조수진(35200321000) | * |
dc.contributor.scopusid | 박보현(14424382500) | * |
dc.contributor.scopusid | 이혜아(57188947704) | * |
dc.date.modifydate | 20240419135248 | * |