DSpace at EWHA: A novel indeno[1,2-b] pyridinone derivative, a DNA intercalative human topoisomerase IIα catalytic inhibitor, for caspase 3-independent anticancer activity

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DC Field	Value	Language
dc.contributor.author	권영주	*
dc.date.accessioned	2018-12-07T16:30:33Z	-
dc.date.available	2018-12-07T16:30:33Z	-
dc.date.issued	2017	*
dc.identifier.issn	1359-7345	*
dc.identifier.other	OAK-20908	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/247350	-
dc.description.abstract	A novel 2-(furan-2-yl)-4-(pyridin-2-yl)-5H-indeno[1,2-b]pyridin-5-one (TI-1-190) was synthesized using a simple microwave-assisted method and its mode of action was systematically characterized. It is a DNA intercalative human topoisomerase IIα catalytic inhibitor with much stronger activity and less DNA toxicity than etoposide, a topoisomerase II poison. TI-1-190 displays caspase 3-independent anticancer activity, unlike etoposide. © 2017 The Royal Society of Chemistry.	*
dc.language	English	*
dc.publisher	Royal Society of Chemistry	*
dc.title	A novel indeno[1,2-b] pyridinone derivative, a DNA intercalative human topoisomerase IIα catalytic inhibitor, for caspase 3-independent anticancer activity	*
dc.type	Article	*
dc.relation.issue	51	*
dc.relation.volume	53	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	6864	*
dc.relation.lastpage	6867	*
dc.relation.journaltitle	Chemical Communications	*
dc.identifier.doi	10.1039/c7cc02372c	*
dc.identifier.wosid	WOS:000404282900013	*
dc.identifier.scopusid	2-s2.0-85021767786	*
dc.author.google	Jeon K.H.	*
dc.author.google	Park C.	*
dc.author.google	Kadayat T.M.	*
dc.author.google	Shrestha A.	*
dc.author.google	Lee E.S.	*
dc.author.google	Kwon Y.	*
dc.contributor.scopusid	권영주(12446435600)	*
dc.date.modifydate	20240123101932	*