Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2018-12-07T16:30:33Z | - |
dc.date.available | 2018-12-07T16:30:33Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1359-7345 | * |
dc.identifier.other | OAK-20908 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247350 | - |
dc.description.abstract | A novel 2-(furan-2-yl)-4-(pyridin-2-yl)-5H-indeno[1,2-b]pyridin-5-one (TI-1-190) was synthesized using a simple microwave-assisted method and its mode of action was systematically characterized. It is a DNA intercalative human topoisomerase IIα catalytic inhibitor with much stronger activity and less DNA toxicity than etoposide, a topoisomerase II poison. TI-1-190 displays caspase 3-independent anticancer activity, unlike etoposide. © 2017 The Royal Society of Chemistry. | * |
dc.language | English | * |
dc.publisher | Royal Society of Chemistry | * |
dc.title | A novel indeno[1,2-b] pyridinone derivative, a DNA intercalative human topoisomerase IIα catalytic inhibitor, for caspase 3-independent anticancer activity | * |
dc.type | Article | * |
dc.relation.issue | 51 | * |
dc.relation.volume | 53 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 6864 | * |
dc.relation.lastpage | 6867 | * |
dc.relation.journaltitle | Chemical Communications | * |
dc.identifier.doi | 10.1039/c7cc02372c | * |
dc.identifier.wosid | WOS:000404282900013 | * |
dc.identifier.scopusid | 2-s2.0-85021767786 | * |
dc.author.google | Jeon K.H. | * |
dc.author.google | Park C. | * |
dc.author.google | Kadayat T.M. | * |
dc.author.google | Shrestha A. | * |
dc.author.google | Lee E.S. | * |
dc.author.google | Kwon Y. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |