DSpace at EWHA: 2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent

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DC Field	Value	Language
dc.contributor.author	권영주	*
dc.date.accessioned	2018-12-07T16:30:32Z	-
dc.date.available	2018-12-07T16:30:32Z	-
dc.date.issued	2017	*
dc.identifier.issn	0960-894X	*
dc.identifier.other	OAK-21015	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/247344	-
dc.description.abstract	A new series of 2-chloropheny-substituted benzofuro[3,2-b]pyridines were designed, synthesized, and evaluated for topoisomerase I and II inhibition and antiproliferative activity. Compounds 17–19, 23, 24, 26, and 27 exhibited excellent topo II inhibitory activity. A systematic structure-activity relationship study revealed the important role of chlorine substitution in the strong topoisomerase inhibitory activity. © 2017 Elsevier Ltd	*
dc.description.sponsorship	Ministry of Education, Science and Technology	*
dc.language	English	*
dc.publisher	Elsevier Ltd	*
dc.subject	Antiproliferative activity	*
dc.subject	Benzofuro[3,2-b]pyridines	*
dc.subject	Chlorine-substituent	*
dc.subject	Heterocycles	*
dc.subject	Topoisomerase I and II inhibition	*
dc.title	2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent	*
dc.type	Article	*
dc.relation.issue	15	*
dc.relation.volume	27	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	3279	*
dc.relation.lastpage	3283	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	*
dc.identifier.doi	10.1016/j.bmcl.2017.06.025	*
dc.identifier.wosid	WOS:000405106500013	*
dc.identifier.scopusid	2-s2.0-85020548858	*
dc.author.google	Thapa Magar T.B.	*
dc.author.google	Kadayat T.M.	*
dc.author.google	Lee H.-J.	*
dc.author.google	Park S.	*
dc.author.google	Bist G.	*
dc.author.google	Shrestha A.	*
dc.author.google	Kwon Y.	*
dc.author.google	Lee E.-S.	*
dc.contributor.scopusid	권영주(12446435600)	*
dc.date.modifydate	20240422124907	*