Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2018-12-07T16:30:32Z | - |
dc.date.available | 2018-12-07T16:30:32Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0960-894X | * |
dc.identifier.other | OAK-21015 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247344 | - |
dc.description.abstract | A new series of 2-chloropheny-substituted benzofuro[3,2-b]pyridines were designed, synthesized, and evaluated for topoisomerase I and II inhibition and antiproliferative activity. Compounds 17–19, 23, 24, 26, and 27 exhibited excellent topo II inhibitory activity. A systematic structure-activity relationship study revealed the important role of chlorine substitution in the strong topoisomerase inhibitory activity. © 2017 Elsevier Ltd | * |
dc.description.sponsorship | Ministry of Education, Science and Technology | * |
dc.language | English | * |
dc.publisher | Elsevier Ltd | * |
dc.subject | Antiproliferative activity | * |
dc.subject | Benzofuro[3,2-b]pyridines | * |
dc.subject | Chlorine-substituent | * |
dc.subject | Heterocycles | * |
dc.subject | Topoisomerase I and II inhibition | * |
dc.title | 2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent | * |
dc.type | Article | * |
dc.relation.issue | 15 | * |
dc.relation.volume | 27 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 3279 | * |
dc.relation.lastpage | 3283 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry Letters | * |
dc.identifier.doi | 10.1016/j.bmcl.2017.06.025 | * |
dc.identifier.wosid | WOS:000405106500013 | * |
dc.identifier.scopusid | 2-s2.0-85020548858 | * |
dc.author.google | Thapa Magar T.B. | * |
dc.author.google | Kadayat T.M. | * |
dc.author.google | Lee H.-J. | * |
dc.author.google | Park S. | * |
dc.author.google | Bist G. | * |
dc.author.google | Shrestha A. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Lee E.-S. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |