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Accuracy assessment of five equations used for estimating the glomerular filtration rate in Korean adults

Title
Accuracy assessment of five equations used for estimating the glomerular filtration rate in Korean adults
Authors
Jeong T.-D.Cho E.-J.Lee W.Chun S.Hong K.-S.Min W.-K.
Ewha Authors
홍기숙정태동
SCOPUS Author ID
홍기숙scopus; 정태동scopus
Issue Date
2017
Journal Title
Annals of Laboratory Medicine
ISSN
2234-3806JCR Link
Citation
Annals of Laboratory Medicine vol. 37, no. 5, pp. 371 - 380
Keywords
AccuracyComparisonCreatinineEquationGlomerular filtration rate
Publisher
Seoul National University, Institute for Cognitive Science
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Background: We aimed to assess the performance of the five creatinine-based equations commonly used for estimates of the glomerular filtration rate (EGFR), namely, the creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPIcr), Asian CKD-EPI, revised Lund-Malmö (revised LM), full age spectrum (FAS), and Korean FAS equations, in the Korean population. Methods: A total of 1, 312 patients, aged 20 yr and above who underwent 51Cr-EDTA GFR measurements (mGFR), were enrolled. The bias (EGFR-mGFR) and precision (root mean square error [RMSE]) were calculated. The accuracy (P30) of four EGFR equations was compared to that of the CKD-EPIcr equation. P30 was defined as the percentage of patients whose EGFR was within±30% of the mGFR. Results: The mean bias (mL·min-1·1.73 m-2) of the five EGFR equation was as follows: CKD-EPIcr, -0.6; Asian CKD-EPI, 2.7; revised LM, -6.5; FAS, -2.5; and Korean FAS, -0.2. The bias of the Asian CKD-EPI, revised LM, and FAS equations showed a significant difference from zero (P<0.001). The RMSE values were as follows: CKD-EPIcr, 15.6; Asian CKD-EPI, 15.6; revised LM, 17.9; FAS, 16.3; and Korean FAS, 15.8. There were no significant differences in the P30 except for the Asian CKD-EPI equation: CKD-EPIcr, 76.6%; Asian CKD-EPI, 74.7%; revised LM, 75.8%; FAS, 76.0%; and Korean FAS, 75.8%. Conclusions: The CKD-EPIcr and Korean FAS equations showed equivalent analytical and clinical performances in the Korean adult population. © 2017 Korean Society for Laboratory Medicine.
DOI
10.3343/alm.2017.37.5.371
Appears in Collections:
의과대학 > 의학과 > Journal papers
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