Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이윤실 | * |
dc.date.accessioned | 2018-12-07T16:30:25Z | - |
dc.date.available | 2018-12-07T16:30:25Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1949-2553 | * |
dc.identifier.other | OAK-21292 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247306 | - |
dc.description.abstract | The regulatory role of suppressor of cytokine signaling 1 (SOCS1) in inflammation has been reported. However, its role in allergic inflammation has not been previously reported. SOCS1 mediated in vitro and in vivo allergic inflammation. Histone deacetylase-3 (HDAC3), a mediator of allergic inflammation, interacted with SOCS1, and miR-384 inhibitor, a positive regulator of HDAC3, induced features of allergic inflammation in an SOCS1-dependent manner. miRNA array analysis showed that the expression of miR-122 was decreased by antigen-stimulation. TargetScan analysis predicted the binding of miR-122 to the 3'-UTR of SOCS1. miR-122 inhibitor induced in vitro and in vivo allergic features in SOCS1-dependent manner. SOCS1 was necessary for allergic inflammation-promoted enhanced tumorigenic and metastatic potential of cancer cells. SOCS1 and miR-122 regulated cellular interactions involving cancer cells, mast cells and macrophages during allergic inflammation. SOCS1 mimetic peptide, D-T-H-F-R-T-F-R-S-H-S-D-Y-R-R-I, inhibited in vitro and in vivo allergic inflammation, allergic inflammation-promoted enhanced tumorigenic and metastatic potential of cancer cells, and cellular interactions during allergic inflammation. Janus kinase 2 (JAK2) exhibited binding to SOCS1 mimetic peptide and mediated allergic inflammation. Transforming growth factor- β1 (TGF-β1) was decreased during allergic inflammation and showed an anti-allergic effect. SOCS1 and JAK2 regulated the production of anti-allergic TGF-β1. Taken together, our results show that miR-122- SOCS1 feedback loop can be employed as a target for the development of anti-allergic and anti-cancer drugs. © Noh et al. | * |
dc.language | English | * |
dc.publisher | Impact Journals LLC | * |
dc.subject | Allergic inflammation | * |
dc.subject | Cellular interaction | * |
dc.subject | MiR-122 | * |
dc.subject | SOCS1 | * |
dc.subject | Tumor microenvironments | * |
dc.title | miR-122-SOCS1-JAK2 axis regulates allergic inflammation and allergic inflammation-promoted cellular interactions | * |
dc.type | Article | * |
dc.relation.issue | 38 | * |
dc.relation.volume | 8 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 63155 | * |
dc.relation.lastpage | 63176 | * |
dc.relation.journaltitle | Oncotarget | * |
dc.identifier.doi | 10.18632/oncotarget.19149 | * |
dc.identifier.wosid | WOS:000410284800030 | * |
dc.identifier.scopusid | 2-s2.0-85029800884 | * |
dc.author.google | Noh K. | * |
dc.author.google | Kim M. | * |
dc.author.google | Kim Y. | * |
dc.author.google | Kim H. | * |
dc.author.google | Byun J. | * |
dc.author.google | Park Y. | * |
dc.author.google | Lee H. | * |
dc.author.google | Lee Y.S. | * |
dc.author.google | Choe J. | * |
dc.author.google | Kim Y.M. | * |
dc.author.google | Jeoung D. | * |
dc.contributor.scopusid | 이윤실(17137192000) | * |
dc.date.modifydate | 20240130115944 | * |