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Prognostic impact of elective supraclavicular nodal irradiation for patients with N1 breast cancer after lumpectomy and anthracycline plus taxane-based chemotherapy (KROG 1418): A multicenter case-controlled study

Title
Prognostic impact of elective supraclavicular nodal irradiation for patients with N1 breast cancer after lumpectomy and anthracycline plus taxane-based chemotherapy (KROG 1418): A multicenter case-controlled study
Authors
Kim H.Park W.Yu J.I.Choi D.H.Huh S.J.Kim Y.-J.Lee E.S.Lee K.S.Kang H.-S.Park I.H.Shin K.H.Wee C.W.Kim K.Park K.R.Kim Y.B.Ahn S.J.Lee J.H.Kim J.H.Chun M.Lee H.-S.Kim J.S.Cha J.
Ewha Authors
김규보박경란
SCOPUS Author ID
김규보scopus; 박경란scopus
Issue Date
2017
Journal Title
Cancer Research and Treatment
ISSN
1598-2998JCR Link
Citation
Cancer Research and Treatment vol. 49, no. 4, pp. 970 - 980
Keywords
Adjuvant radiotherapyBreast neoplasmsCase-control studiesLymphatic irradiationTaxane
Publisher
Korean Cancer Association
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Purpose This study was conducted to evaluate the impact of supraclavicular lymph node radiotherapy (SCNRT) on N1 breast cancer patients receiving post-lumpectomy whole-breast irradiation (WBI) and anthracycline plus taxane-based (AT) chemotherapy. Materials and Methods We performed a case-control analysis to compare the outcomes of WBI and WBI plus SCNRT (WBI+SCNRT). Among 1,147 patients with N1 breast cancer who received post-lumpectomy radiotherapy and AT-based chemotherapy in 12 hospitals, 542 were selected after propensity score matching. Patterns of failure, disease-free survival (DFS), distant metastasis-free survival (DMFS), and treatment-related toxicity were compared between groups. Results A total of 41 patients (7.6%) were found to have recurrence. Supraclavicular lymph node (SCN) failure was detected in three patients, two in WBI and one in WBI+SCNRT. All SCN failures were found simultaneously with distant metastasis. There was no significant difference in patterns of failure or survival between groups. The 5-year DFS and DMFS for patients with WBI and WBI+SCNRT were 94.4% versus 92.6% (p=0.50) and 95.1% versus 94.5% (p=0.99), respectively. The rates of lymphedema and radiation pneumonitis were significantly higher in the WBI+SCNRT than in the WBI. Conclusion We did not find a benefit of SCNRT for N1 breast cancer patients receiving AT-based chemotherapy. © 2017 by the Korean Cancer Association.
DOI
10.4143/crt.2016.382
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의과대학 > 의학과 > Journal papers
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