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Reproductive factors as risk modifiers of breast cancer in BRCA mutation carriers and high-risk non-carriers

Title
Reproductive factors as risk modifiers of breast cancer in BRCA mutation carriers and high-risk non-carriers
Authors
Park, BoyoungHopper, John L.Win, Aung K.Dowty, James G.Sung, Ho KyungAhn, ChoonghyunKim, Sung-WonLee, Min HyukLee, JihyounLee, Jong WonKang, EunyoungYu, Jong-HanKim, Ku SangMoon, Byung-InHan, WonshikNoh, Dong-YoungPark, Sue K.KOHBRA Study Grp
Ewha Authors
문병인
SCOPUS Author ID
문병인scopus
Issue Date
2017
Journal Title
ONCOTARGET
ISSN
1949-2553JCR Link
Citation
ONCOTARGET vol. 8, no. 60, pp. 102110 - 102118
Keywords
breast neoplasmreproductive factorsBRCA1/2 mutation carriersfamilial breast cancerearly onset breast cancer
Publisher
IMPACT JOURNALS LLC
Indexed
SCOPUS WOS scopus
Document Type
Article
Abstract
This study was conducted to identify the role of reproductive factors as environmental modifiers for breast cancer (BC) risk in clinic-based, East-Asian BRCA1 and BRCA2 mutation carriers and non-carriers with high-risk criteria of BRCA mutations (family history (FH) of BC, early-onset BC (aged <= 40 years)). A total of 581 women who were BRCA carriers (222 BRCA1 and 359 BRCA2), 1,083 non-carriers with FH, and 886 non-carriers with early-onset BC were enrolled and interviewed to examine the reproductive factors, from 2007 to 2014. The hazard ratio (HR) and its 95% confidence interval (CI) in the weighted Cox regression model were used to calculate the BC risk based on the reproductive factors. Earlier menarche increased BC risk by 3.49-fold in BRCA2 mutation carriers (95% CI=2.03-6.00) and 3.30-fold in non-carriers with FH (95% CI=1.73-6.34), but was insignificantly associated with BRCA1 carriers and non-carriers for early-onset BC (P-heterogeneity=0.047). Higher parity decreased BC risk in BRCA carriers and non-carriers with FH, especially in BRCA1 carriers (HR=0.27, 95% CI=0.09-0.83 for two parity; and HR=0.23, 95% CI=0.05-1.00 for >= 3 parity), but increased the early-onset BC risk (HR=4.63, 95% CI=2.56-8.51 for > 3 parity, p-heterogeneity=0.045). Oral contraceptive (OC) use and longer estrogen exposure periods (>= 30 years) were associated with an increased risk of early-onset BC (HR=3.99, 95% CI=1.65-9.67; HR=7.69, 95% CI=1.96-25.01), while OC use was not associated with BC risk in other groups and longer estrogen exposure had rather decreased risk for BC risk (both p-heterogeneity<0.001). Several reproductive factors as risk modifiers could heterogeneously be associated with BC among BRCA1/2 mutation carriers, non-carriers with FH, and early-onset BC non-carriers.
DOI
10.18632/oncotarget.22193
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의과대학 > 의학과 > Journal papers
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