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Reproductive factors as risk modifiers of breast cancer in BRCA mutation carriers and high-risk non-carriers
- Title
- Reproductive factors as risk modifiers of breast cancer in BRCA mutation carriers and high-risk non-carriers
- Authors
- Park, Boyoung; Hopper, John L.; Win, Aung K.; Dowty, James G.; Sung, Ho Kyung; Ahn, Choonghyun; Kim, Sung-Won; Lee, Min Hyuk; Lee, Jihyoun; Lee, Jong Won; Kang, Eunyoung; Yu, Jong-Han; Kim, Ku Sang; Moon, Byung-In; Han, Wonshik; Noh, Dong-Young; Park, Sue K.|KOHBRA Study Grp
- Ewha Authors
- 문병인
- SCOPUS Author ID
- 문병인
- Issue Date
- 2017
- Journal Title
- ONCOTARGET
- ISSN
- 1949-2553
- Citation
- ONCOTARGET vol. 8, no. 60, pp. 102110 - 102118
- Keywords
- breast neoplasm; reproductive factors; BRCA1/2 mutation carriers; familial breast cancer; early onset breast cancer
- Publisher
- IMPACT JOURNALS LLC
- Indexed
- SCOPUS
- Document Type
- Article
- Abstract
- This study was conducted to identify the role of reproductive factors as environmental modifiers for breast cancer (BC) risk in clinic-based, East-Asian BRCA1 and BRCA2 mutation carriers and non-carriers with high-risk criteria of BRCA mutations (family history (FH) of BC, early-onset BC (aged <= 40 years)). A total of 581 women who were BRCA carriers (222 BRCA1 and 359 BRCA2), 1,083 non-carriers with FH, and 886 non-carriers with early-onset BC were enrolled and interviewed to examine the reproductive factors, from 2007 to 2014. The hazard ratio (HR) and its 95% confidence interval (CI) in the weighted Cox regression model were used to calculate the BC risk based on the reproductive factors. Earlier menarche increased BC risk by 3.49-fold in BRCA2 mutation carriers (95% CI=2.03-6.00) and 3.30-fold in non-carriers with FH (95% CI=1.73-6.34), but was insignificantly associated with BRCA1 carriers and non-carriers for early-onset BC (P-heterogeneity=0.047). Higher parity decreased BC risk in BRCA carriers and non-carriers with FH, especially in BRCA1 carriers (HR=0.27, 95% CI=0.09-0.83 for two parity; and HR=0.23, 95% CI=0.05-1.00 for >= 3 parity), but increased the early-onset BC risk (HR=4.63, 95% CI=2.56-8.51 for > 3 parity, p-heterogeneity=0.045). Oral contraceptive (OC) use and longer estrogen exposure periods (>= 30 years) were associated with an increased risk of early-onset BC (HR=3.99, 95% CI=1.65-9.67; HR=7.69, 95% CI=1.96-25.01), while OC use was not associated with BC risk in other groups and longer estrogen exposure had rather decreased risk for BC risk (both p-heterogeneity<0.001). Several reproductive factors as risk modifiers could heterogeneously be associated with BC among BRCA1/2 mutation carriers, non-carriers with FH, and early-onset BC non-carriers.
- DOI
- 10.18632/oncotarget.22193
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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Reproductive factors.pdf(1.78 MB)
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