Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 문병인 | * |
dc.date.accessioned | 2018-11-23T16:30:10Z | - |
dc.date.available | 2018-11-23T16:30:10Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1949-2553 | * |
dc.identifier.other | OAK-23761 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247027 | - |
dc.description.abstract | This study was conducted to identify the role of reproductive factors as environmental modifiers for breast cancer (BC) risk in clinic-based, East-Asian BRCA1 and BRCA2 mutation carriers and non-carriers with high-risk criteria of BRCA mutations (family history (FH) of BC, early-onset BC (aged <= 40 years)). A total of 581 women who were BRCA carriers (222 BRCA1 and 359 BRCA2), 1,083 non-carriers with FH, and 886 non-carriers with early-onset BC were enrolled and interviewed to examine the reproductive factors, from 2007 to 2014. The hazard ratio (HR) and its 95% confidence interval (CI) in the weighted Cox regression model were used to calculate the BC risk based on the reproductive factors. Earlier menarche increased BC risk by 3.49-fold in BRCA2 mutation carriers (95% CI=2.03-6.00) and 3.30-fold in non-carriers with FH (95% CI=1.73-6.34), but was insignificantly associated with BRCA1 carriers and non-carriers for early-onset BC (P-heterogeneity=0.047). Higher parity decreased BC risk in BRCA carriers and non-carriers with FH, especially in BRCA1 carriers (HR=0.27, 95% CI=0.09-0.83 for two parity; and HR=0.23, 95% CI=0.05-1.00 for >= 3 parity), but increased the early-onset BC risk (HR=4.63, 95% CI=2.56-8.51 for > 3 parity, p-heterogeneity=0.045). Oral contraceptive (OC) use and longer estrogen exposure periods (>= 30 years) were associated with an increased risk of early-onset BC (HR=3.99, 95% CI=1.65-9.67; HR=7.69, 95% CI=1.96-25.01), while OC use was not associated with BC risk in other groups and longer estrogen exposure had rather decreased risk for BC risk (both p-heterogeneity<0.001). Several reproductive factors as risk modifiers could heterogeneously be associated with BC among BRCA1/2 mutation carriers, non-carriers with FH, and early-onset BC non-carriers. | * |
dc.language | English | * |
dc.publisher | IMPACT JOURNALS LLC | * |
dc.subject | breast neoplasm | * |
dc.subject | reproductive factors | * |
dc.subject | BRCA1/2 mutation carriers | * |
dc.subject | familial breast cancer | * |
dc.subject | early onset breast cancer | * |
dc.title | Reproductive factors as risk modifiers of breast cancer in BRCA mutation carriers and high-risk non-carriers | * |
dc.type | Article | * |
dc.relation.issue | 60 | * |
dc.relation.volume | 8 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 102110 | * |
dc.relation.lastpage | 102118 | * |
dc.relation.journaltitle | ONCOTARGET | * |
dc.identifier.doi | 10.18632/oncotarget.22193 | * |
dc.identifier.wosid | WOS:000419533200092 | * |
dc.identifier.scopusid | 2-s2.0-85034852534 | * |
dc.author.google | Park, Boyoung | * |
dc.author.google | Hopper, John L. | * |
dc.author.google | Win, Aung K. | * |
dc.author.google | Dowty, James G. | * |
dc.author.google | Sung, Ho Kyung | * |
dc.author.google | Ahn, Choonghyun | * |
dc.author.google | Kim, Sung-Won | * |
dc.author.google | Lee, Min Hyuk | * |
dc.author.google | Lee, Jihyoun | * |
dc.author.google | Lee, Jong Won | * |
dc.author.google | Kang, Eunyoung | * |
dc.author.google | Yu, Jong-Han | * |
dc.author.google | Kim, Ku Sang | * |
dc.author.google | Moon, Byung-In | * |
dc.author.google | Han, Wonshik | * |
dc.author.google | Noh, Dong-Young | * |
dc.author.google | Park, Sue K.|KOHBRA Study Grp | * |
dc.contributor.scopusid | 문병인(7101878644;56119062300) | * |
dc.date.modifydate | 20231116123537 | * |