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dc.contributor.author문병인-
dc.date.accessioned2018-11-23T16:30:10Z-
dc.date.available2018-11-23T16:30:10Z-
dc.date.issued2017-
dc.identifier.issn1949-2553-
dc.identifier.otherOAK-23761-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/247027-
dc.description.abstractThis study was conducted to identify the role of reproductive factors as environmental modifiers for breast cancer (BC) risk in clinic-based, East-Asian BRCA1 and BRCA2 mutation carriers and non-carriers with high-risk criteria of BRCA mutations (family history (FH) of BC, early-onset BC (aged <= 40 years)). A total of 581 women who were BRCA carriers (222 BRCA1 and 359 BRCA2), 1,083 non-carriers with FH, and 886 non-carriers with early-onset BC were enrolled and interviewed to examine the reproductive factors, from 2007 to 2014. The hazard ratio (HR) and its 95% confidence interval (CI) in the weighted Cox regression model were used to calculate the BC risk based on the reproductive factors. Earlier menarche increased BC risk by 3.49-fold in BRCA2 mutation carriers (95% CI=2.03-6.00) and 3.30-fold in non-carriers with FH (95% CI=1.73-6.34), but was insignificantly associated with BRCA1 carriers and non-carriers for early-onset BC (P-heterogeneity=0.047). Higher parity decreased BC risk in BRCA carriers and non-carriers with FH, especially in BRCA1 carriers (HR=0.27, 95% CI=0.09-0.83 for two parity; and HR=0.23, 95% CI=0.05-1.00 for >= 3 parity), but increased the early-onset BC risk (HR=4.63, 95% CI=2.56-8.51 for > 3 parity, p-heterogeneity=0.045). Oral contraceptive (OC) use and longer estrogen exposure periods (>= 30 years) were associated with an increased risk of early-onset BC (HR=3.99, 95% CI=1.65-9.67; HR=7.69, 95% CI=1.96-25.01), while OC use was not associated with BC risk in other groups and longer estrogen exposure had rather decreased risk for BC risk (both p-heterogeneity<0.001). Several reproductive factors as risk modifiers could heterogeneously be associated with BC among BRCA1/2 mutation carriers, non-carriers with FH, and early-onset BC non-carriers.-
dc.languageEnglish-
dc.publisherIMPACT JOURNALS LLC-
dc.subjectbreast neoplasm-
dc.subjectreproductive factors-
dc.subjectBRCA1/2 mutation carriers-
dc.subjectfamilial breast cancer-
dc.subjectearly onset breast cancer-
dc.titleReproductive factors as risk modifiers of breast cancer in BRCA mutation carriers and high-risk non-carriers-
dc.typeArticle-
dc.relation.issue60-
dc.relation.volume8-
dc.relation.indexSCOPUS-
dc.relation.startpage102110-
dc.relation.lastpage102118-
dc.relation.journaltitleONCOTARGET-
dc.identifier.doi10.18632/oncotarget.22193-
dc.identifier.wosidWOS:000419533200092-
dc.identifier.scopusid2-s2.0-85034852534-
dc.author.googlePark, Boyoung-
dc.author.googleHopper, John L.-
dc.author.googleWin, Aung K.-
dc.author.googleDowty, James G.-
dc.author.googleSung, Ho Kyung-
dc.author.googleAhn, Choonghyun-
dc.author.googleKim, Sung-Won-
dc.author.googleLee, Min Hyuk-
dc.author.googleLee, Jihyoun-
dc.author.googleLee, Jong Won-
dc.author.googleKang, Eunyoung-
dc.author.googleYu, Jong-Han-
dc.author.googleKim, Ku Sang-
dc.author.googleMoon, Byung-In-
dc.author.googleHan, Wonshik-
dc.author.googleNoh, Dong-Young-
dc.author.googlePark, Sue K.-
dc.author.googleKOHBRA Study Grp-
dc.contributor.scopusid문병인(7101878644)-
dc.date.modifydate20191114141602-


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