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Naphthalene-based fluorescent probes for glutathione and their applications in living cells and patients with sepsis

Title
Naphthalene-based fluorescent probes for glutathione and their applications in living cells and patients with sepsis
Authors
Li J.Kwon Y.Chung K.S.Lim C.S.Lee D.Yue Y.Yoon J.Kim G.Nam S.-J.Chung Y.W.Kim H.M.Yin C.Ryu J.-H.
Ewha Authors
윤주영남상집
SCOPUS Author ID
윤주영scopus; 남상집scopus
Issue Date
2018
Journal Title
Theranostics
ISSN
1838-7640JCR Link
Citation
Theranostics vol. 8, no. 5, pp. 1411 - 1420
Keywords
Cell imagingDiagnosisFluorescence probeGSHSepsis
Publisher
Ivyspring International Publisher
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Rationale: Among the biothiols-related diseases, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection and can result in severe oxidative stress and damage to multiple organs. In this study, we aimed to develop a fluorescence chemosensor that can both detect GSH and further predict sepsis. Methods: In this study, two new naphthalene dialdehyde compounds containing different functional groups were synthesized, and the sensing abilities of these compounds towards biothiols and its applications for prediction of sepsis were investigated. Results: Our study revealed that the newly developed probe 6-methoxynaphthalene-2, 3-dicarbaldehyde (MNDA) has two-photon is capable of detecting GSH in live cells with two-photon microscopy (TPM) under the excitation at a wavelength of 900 nm. Furthermore, two GSH detection probes naphthalene-2,3-dicarboxaldehyde (NDA) and 6-fluoronaphthalene-2,3- dicarbaldehyde (FNDA) not only can detect GSH in living cells, but also showed clinical significance for the diagnosis and prediction of mortality in patients with sepsis. Conclusions: These results open up a promising direction for further medical diagnostic techniques. © Ivyspring International Publisher.
DOI
10.7150/thno.22252
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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