Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2018-11-21T16:30:48Z | - |
dc.date.available | 2018-11-21T16:30:48Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1350-9047 | * |
dc.identifier.issn | 1476-5403 | * |
dc.identifier.other | OAK-22066 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/246866 | - |
dc.description.abstract | The receptor activator of nuclear factor-kappa B (RANK) protein activates various protein kinase signaling cascades, including those involving NF-kappa B, mitogen-activated protein kinase (MAPK), and Bruton tyrosine kinase (Btk)/tyrosine-protein kinase Tec. However, the mechanism underlying the negative regulation of RANK by downstream signaling molecules remains unclear. Here, we report that Src homology 3 domain and cysteine-rich domain-containing protein 2 (STAC2) is a novel RANK ligand-inducible protein that negatively regulates RANK-mediated osteoclast formation. STAC2 physically interacts with RANK and inhibits the formation of the RANK signaling complex, which contains Grb-2-associated binder 2 (Gab2) and phospholipase C gamma 2 (PLC gamma 2), thus leading to the suppression of RANK-mediated NF-kappa B and MAPK activation. Furthermore, STAC2 overexpression limits Btk/Tec-mediated PLC gamma 2 phosphorylation via the interaction between STAC2 and Btk/Tec. Taken together, our results reveal a novel mechanism whereby RANK signaling is restricted by its physical interaction with STAC2. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | STAC2 negatively regulates osteoclast formation by targeting the RANK signaling complex | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 25 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1364 | * |
dc.relation.lastpage | 1374 | * |
dc.relation.journaltitle | CELL DEATH AND DIFFERENTIATION | * |
dc.identifier.doi | 10.1038/s41418-017-0048-5 | * |
dc.identifier.wosid | WOS:000442884000002 | * |
dc.identifier.scopusid | 2-s2.0-85040653203 | * |
dc.author.google | Jeong, Eutteum | * |
dc.author.google | Choi, Han Kyoung | * |
dc.author.google | Park, Jin Hee | * |
dc.author.google | Lee, Soo Young | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |