View : 39 Download: 12
Prevalence and serogroup changes of Neisseria meningitidis in South Korea
- Prevalence and serogroup changes of Neisseria meningitidis in South Korea
- Lee H.; Seo Y.; Kim K.-H.; Lee K.; Choe K.-W.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Scientific Reports
- Scientific Reports vol. 8, no. 1
- Nature Publishing Group
- SCIE; SCOPUS; SCI
- Document Type
- Determination of the major serogroups is an important step for establishing a vaccine programme and management strategy targeting Neisseria meningitidis. From April 2010 to November 2016, a total of 25 N. meningitidis isolates were collected in South Korea, in collaboration with the Korean Society of Clinical Microbiology. Among isolates, 19 isolates were recovered from blood and/or cerebrospinal fluid (CSF) in 46 patients who suffered from invasive meningococcal disease (IMD), and six isolates were found in sputum or the throat. The most common serogroup was serogroup B (overall, 36%, n = 9/25; IMD, 37%, n = 7/19), which was isolated in every year of the research period except for 2011. There were five serogroup W isolates recovered from patients in military service. W was no longer isolated after initiation of a vaccine programme for military trainees, but serogroup B caused meningitis in an army recruit training centre in 2015. In MLST analysis, 14 sequence types were found, and all isolates belonging to W showed the same molecular epidemiologic characteristics (W:P1.5-1, 2-2:F3-9:ST-8912). All isolates showed susceptibility to ceftriaxone, meropenem, ciprofloxacin, minocycline, and rifampin; however, the susceptibility rates to penicillin and ampicillin for isolates with W and C capsules were 22% and 30%, respectively. © 2018 The Author(s).
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
Prevalence and serogroup changes.pdf(1.21 MB)
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.