Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오억수 | * |
dc.contributor.author | 임경민 | * |
dc.date.accessioned | 2018-11-21T16:30:25Z | - |
dc.date.available | 2018-11-21T16:30:25Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1755-1471 | * |
dc.identifier.other | OAK-22337 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/246742 | - |
dc.description.abstract | Although L-tyrosine is well known for its melanogenic effect, the contribution of D-tyrosine to melanin synthesis was previously unexplored. Here, we reveal that, unlike L-tyrosine, D-tyrosine dose-dependently reduced the melanin contents of human MNT-1 melanoma cells and primary human melanocytes. In addition, 500 μM of D-tyrosine completely inhibited 10 μM L-tyrosine-induced melanogenesis, and both in vitro assays and L-DOPA staining MNT-1 cells showed that tyrosinase activity is reduced by D-tyrosine treatment. Thus, D-tyrosine appears to inhibit L-tyrosine-mediated melanogenesis by competitively inhibiting tyrosinase activity. Furthermore, we found that D-tyrosine inhibited melanogenesis induced by α-MSH treatment or UV irradiation, which are the most common environmental factors responsible for melanin synthesis. Finally, we confirmed that D-tyrosine reduced melanin synthesis in the epidermal basal layer of a 3D human skin model. Taken together, these data suggest that D-tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity in melanocyte-derived cells. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd | * |
dc.description.sponsorship | National Research Foundation of Korea | * |
dc.language | English | * |
dc.publisher | Blackwell Publishing Ltd | * |
dc.subject | D-tyrosine | * |
dc.subject | L-tyrosine | * |
dc.subject | melanin | * |
dc.subject | melanogenesis | * |
dc.subject | tyrosinase | * |
dc.title | D-tyrosine negatively regulates melanin synthesis by competitively inhibiting tyrosinase activity | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 31 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 374 | * |
dc.relation.lastpage | 383 | * |
dc.relation.journaltitle | Pigment Cell and Melanoma Research | * |
dc.identifier.doi | 10.1111/pcmr.12668 | * |
dc.identifier.wosid | WOS:000429325300004 | * |
dc.identifier.scopusid | 2-s2.0-85044942163 | * |
dc.author.google | Park J. | * |
dc.author.google | Jung H. | * |
dc.author.google | Kim K. | * |
dc.author.google | Lim K.-M. | * |
dc.author.google | Kim J.-Y. | * |
dc.author.google | Jho E.-H. | * |
dc.author.google | Oh E.-S. | * |
dc.contributor.scopusid | 오억수(7101967153) | * |
dc.contributor.scopusid | 임경민(8916551700) | * |
dc.date.modifydate | 20240527131426 | * |