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Decursin and Z-Ligustilide in Angelica tenuissima Root Extract Fermented by Aspergillus oryzae Display Anti-Pigment Activity in Melanoma Cells

Title
Decursin and Z-Ligustilide in Angelica tenuissima Root Extract Fermented by Aspergillus oryzae Display Anti-Pigment Activity in Melanoma Cells
Authors
Park, YunaKim, DayoungYang, InhoChoi, BomeeLee, Jin WooNamkoong, SeungKoo, Hyun JungLee, Sung RyulPark, Myung RyeLim, HyosunKim, Youn KyuNam, Sang-JipSohn, Eun-Hwa
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2018
Journal Title
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
ISSN
1017-7825JCR Link

1738-8872JCR Link
Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY vol. 28, no. 7, pp. 1061 - 1067
Keywords
Angelica tenuissimadecursinZ-ligustilideanti-melanogenic activityAspergillus oryzaefermentation
Publisher
KOREAN SOC MICROBIOLOGY &

BIOTECHNOLOGY
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
The anti-melanogenic effects of the extract of Angelica tenuissima (AT) root and the extract of AT root fermented by Aspergillus oryzae (FAT) were investigated. These effects were determined by measuring the inhibitory activity of AT and FAT on melanin production in B16F10 melanocytes and with in vitro tyrosinase activity assays. The AT extract inhibited melanin production at concentrations above 250 mu g/ml, and this inhibitory effect was significantly enhanced by the fermentation process with A. oryzae. HPLC analysis resulted in the isolation of two active compounds from both the AT and FAT extracts. Their chemical structures were identified as decursin and Z-ligustilide through comparison with previously reported NMR data. The decursin and Z-ligustilide contents were increased in the FAT extract and could be responsible for its enhanced inhibitory effects on melanin production and tyrosinase activity compared with that of the AT extract.
DOI
10.4014/jmb.1812.02044
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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