Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김원기 | - |
dc.date.accessioned | 2018-06-02T08:15:48Z | - |
dc.date.available | 2018-06-02T08:15:48Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0920-1211 | - |
dc.identifier.other | OAK-3901 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/244661 | - |
dc.description.abstract | We examined whether (-)-nicotine infusion can affect kainic acid (KA)-induced neurotoxicity in rats. Although treatment with a single nicotine infusion (0.5 or 1.0 μg/side, i.c.v.) failed to attenuate KA-induced neurotoxicity, repeated nicotine infusions (1.0 μg/side/day for 10 days) attenuated the seizures, the severe loss of cells in hippocampal regions CA1 and CA3, the increase in activator protein (AP)-1 DNA binding activity, and mortality after KA administration. α-Bungarotoxin and mecamylamine blocked the neuroprotective effects of nicotine. These results suggest that repeated nicotine treatment provides α7 nicotinic acetylcholine receptor-mediated neuroprotection against KA toxicity. © 2006 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.title | Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the α7 nicotinic acetylcholine receptor | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 73 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 292 | - |
dc.relation.lastpage | 298 | - |
dc.relation.journaltitle | Epilepsy Research | - |
dc.identifier.doi | 10.1016/j.eplepsyres.2006.11.004 | - |
dc.identifier.wosid | WOS:000245322400010 | - |
dc.identifier.scopusid | 2-s2.0-33847189602 | - |
dc.author.google | Shin E.-J. | - |
dc.author.google | Chae J.S. | - |
dc.author.google | Jung M.-E. | - |
dc.author.google | Bing G. | - |
dc.author.google | Ko K.H. | - |
dc.author.google | Kim W.-K. | - |
dc.author.google | Wie M.B. | - |
dc.author.google | Cheon M.-A. | - |
dc.author.google | Nah S.-Y. | - |
dc.author.google | Kim H.-C. | - |
dc.contributor.scopusid | 김원기(34770946200) | - |
dc.date.modifydate | 20211210152058 | - |