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A case of massive cisplatin overdose managed by plasmapheresis.

Title
A case of massive cisplatin overdose managed by plasmapheresis.
Authors
Jung H.K.Lee J.Lee S.N.
Ewha Authors
이순남이지수정혜경
SCOPUS Author ID
이순남scopus; 이지수scopus; 정혜경scopus
Issue Date
1995
Journal Title
The Korean journal of internal medicine
ISSN
1226-3303JCR Link
Citation
The Korean journal of internal medicine vol. 10, no. 2, pp. 150 - 154
Indexed
SCIE; SCOPUS; KCI scopus
Document Type
Article
Abstract
OBJECTIVES: Accidental cisplatin overdose occurs with increasing frequency despite the safeguards taken in prescription and administration, since cisplatin has been used increasingly for the treatment of numerous malignancies. Accidentally, a 59-year-old male received massive cisplatin overdose of 300mg/m2. METHODS: Laboratory documentation included measurement of cisplatin concentrations by flameless atomic absorption spectroscopy (Varian, Spectra AA 300). RESULTS: Toxicities included severe emesis, myelosuppression, renal failure, mental deterioration with hallucination, dim vision and hepatic toxicity. Plasmapheresis was effective in lowering the platinum concentration from greatest 2979 ng/ml to 185 ng/ml and appeared to be of clinical benefit. Granulocyte-macrophage colony stimulating factor (GM-CSF) was used to ameliorate myelosuppression. The patient's renal function was restored 3 months later and partial response of esophageal cancer was obtained. CONCLUSIONS: Plasmapheresis was effective in lowering the platinum concentration in massive cisplatin overdose. This case heightens awareness to the possibility of accidental cisplatin overdose and the benefits of prompt management.
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의과대학 > 의학과 > Journal papers
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