Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이순남 | - |
dc.contributor.author | 이지수 | - |
dc.contributor.author | 정혜경 | - |
dc.date.accessioned | 2018-06-02T08:15:21Z | - |
dc.date.available | 2018-06-02T08:15:21Z | - |
dc.date.issued | 1995 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.other | OAK-16907 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/244497 | - |
dc.description.abstract | OBJECTIVES: Accidental cisplatin overdose occurs with increasing frequency despite the safeguards taken in prescription and administration, since cisplatin has been used increasingly for the treatment of numerous malignancies. Accidentally, a 59-year-old male received massive cisplatin overdose of 300mg/m2. METHODS: Laboratory documentation included measurement of cisplatin concentrations by flameless atomic absorption spectroscopy (Varian, Spectra AA 300). RESULTS: Toxicities included severe emesis, myelosuppression, renal failure, mental deterioration with hallucination, dim vision and hepatic toxicity. Plasmapheresis was effective in lowering the platinum concentration from greatest 2979 ng/ml to 185 ng/ml and appeared to be of clinical benefit. Granulocyte-macrophage colony stimulating factor (GM-CSF) was used to ameliorate myelosuppression. The patient's renal function was restored 3 months later and partial response of esophageal cancer was obtained. CONCLUSIONS: Plasmapheresis was effective in lowering the platinum concentration in massive cisplatin overdose. This case heightens awareness to the possibility of accidental cisplatin overdose and the benefits of prompt management. | - |
dc.language | English | - |
dc.title | A case of massive cisplatin overdose managed by plasmapheresis. | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 10 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 150 | - |
dc.relation.lastpage | 154 | - |
dc.relation.journaltitle | The Korean journal of internal medicine | - |
dc.identifier.scopusid | 2-s2.0-0029331539 | - |
dc.author.google | Jung H.K. | - |
dc.author.google | Lee J. | - |
dc.author.google | Lee S.N. | - |
dc.contributor.scopusid | 이순남(8422735900;56949372000) | - |
dc.contributor.scopusid | 이지수(14424388700) | - |
dc.contributor.scopusid | 정혜경(7403029723) | - |
dc.date.modifydate | 20230208112902 | - |