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Hyphal growth inhibition by deer antler extract mimics the effect of chitin synthase deletion in Candida albicans

Title
Hyphal growth inhibition by deer antler extract mimics the effect of chitin synthase deletion in Candida albicans
Authors
Park H.Jhon G.-J.Choi W.
Ewha Authors
전길자최원자
SCOPUS Author ID
전길자scopus; 최원자scopus
Issue Date
1998
Journal Title
Journal of Microbiology and Biotechnology
ISSN
1017-7825JCR Link
Citation
Journal of Microbiology and Biotechnology vol. 8, no. 4, pp. 422 - 425
Indexed
SCIE; SCOPUS; KCI scopus
Document Type
Article
Abstract
Chitin synthase null-mutants propagate in yeast form in RPMI medium with suppression of hyphal growth. This hyphal suppression is also observed in the wild type culture grown in RPMI medium supplemented with deer antler extract. To identify the possible target of deer antler extract, the enzymatic activities of chitin synthases were examined. The enzymatic activities of three chitin synthases, CAChs1, CAChs2, and CAChs3, were found to be differentially inhibited by deer antler extract. Of them, CAChs1, was the most sensitive to the extract. These results indicate that deer antler extract causes hyphal suppression, which resembles the effects of chitin synthase deletion, probably through direct inhibition of chitin synthases.
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자연과학대학 > 화학·나노과학전공 > Journal papers
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