Korean Journal of Pharmacognosy vol. 29, no. 4, pp. 312 - 317
In this study, the effect of 70% ethyl alcohol fraction of Cervus nippon (CN-E) on mouse T-lymphocyte was investigated in vivo. The administration of CN-E (100 mg/kg) enhanced the proliferation of thymocytes, the population of CD4+ CD8- single-positive cells and the production of interferon-γ in thymocytes and splenocytes. The administration of CN-E did not induce DNA fragmentation and reduce mitochondrial transmembrane potential in thymocytes. These results indicate that the CN-E contains a stimulative component on the proliferation of thymocytes, the population of T(H) cells and the production of interferon-γ in T-lymphocytes.